Serum amino-terminal propeptide of type III procollagen (PIIINP) levels in patients with acromegaly before and after pituitary adenomectomy

A. Sartorio; M. Monzani; A. Conti; G. Casati; G. Faglia

Serum amino-terminal propeptide of type III procollagen (PIIINP) levels in patients with acromegaly before and after pituitary adenomectomy

A. Sartorio, M. Monzani, A. Conti, G. Casati, G. Faglia

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Growth hormone (GH) plays an important role on both bone and collagen metabolism via systemic insulin-like growth factors (IGF) production or directly by stimulating either the differentiation of precursor cells or the local production of growth factors. In this study we evaluated serum amino- terminal propeptide of type III procollagen (PIIINP) levels, specific and reliable marker of collagen synthesis, in a group of patients with acromegaly (4M, 3F, age range: 29-63 yrs) before and 2, 6 and 9 months after transnasosphenoidal pituitary adenomectomy. In active acromegaly (GH: 23.6±7.6 ng/ml, IGF-I: 140.5±18 nmol/L), mean PIIINP levels were significantly higher than in controls (8.3±1.1 vs 3.3±0.2 ng/ml, p

Original language	English
Pages (from-to)	79-83
Number of pages	5
Journal	European Journal of Internal Medicine, Supplement
Volume	4
Issue number	1
Publication status	Published - 1993

ASJC Scopus subject areas

Medicine(all)
Internal Medicine

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title = "Serum amino-terminal propeptide of type III procollagen (PIIINP) levels in patients with acromegaly before and after pituitary adenomectomy",

abstract = "Growth hormone (GH) plays an important role on both bone and collagen metabolism via systemic insulin-like growth factors (IGF) production or directly by stimulating either the differentiation of precursor cells or the local production of growth factors. In this study we evaluated serum amino- terminal propeptide of type III procollagen (PIIINP) levels, specific and reliable marker of collagen synthesis, in a group of patients with acromegaly (4M, 3F, age range: 29-63 yrs) before and 2, 6 and 9 months after transnasosphenoidal pituitary adenomectomy. In active acromegaly (GH: 23.6±7.6 ng/ml, IGF-I: 140.5±18 nmol/L), mean PIIINP levels were significantly higher than in controls (8.3±1.1 vs 3.3±0.2 ng/ml, p",

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T1 - Serum amino-terminal propeptide of type III procollagen (PIIINP) levels in patients with acromegaly before and after pituitary adenomectomy

AU - Sartorio, A.

AU - Monzani, M.

AU - Conti, A.

AU - Casati, G.

AU - Faglia, G.

PY - 1993

Y1 - 1993

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AB - Growth hormone (GH) plays an important role on both bone and collagen metabolism via systemic insulin-like growth factors (IGF) production or directly by stimulating either the differentiation of precursor cells or the local production of growth factors. In this study we evaluated serum amino- terminal propeptide of type III procollagen (PIIINP) levels, specific and reliable marker of collagen synthesis, in a group of patients with acromegaly (4M, 3F, age range: 29-63 yrs) before and 2, 6 and 9 months after transnasosphenoidal pituitary adenomectomy. In active acromegaly (GH: 23.6±7.6 ng/ml, IGF-I: 140.5±18 nmol/L), mean PIIINP levels were significantly higher than in controls (8.3±1.1 vs 3.3±0.2 ng/ml, p

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