Serum amino-terminal propeptide of type III procollagen (PIIINP) levels in patients with acromegaly before and after pituitary adenomectomy

A. Sartorio, M. Monzani, A. Conti, G. Casati, G. Faglia

Research output: Contribution to journalArticlepeer-review

Abstract

Growth hormone (GH) plays an important role on both bone and collagen metabolism via systemic insulin-like growth factors (IGF) production or directly by stimulating either the differentiation of precursor cells or the local production of growth factors. In this study we evaluated serum amino- terminal propeptide of type III procollagen (PIIINP) levels, specific and reliable marker of collagen synthesis, in a group of patients with acromegaly (4M, 3F, age range: 29-63 yrs) before and 2, 6 and 9 months after transnasosphenoidal pituitary adenomectomy. In active acromegaly (GH: 23.6±7.6 ng/ml, IGF-I: 140.5±18 nmol/L), mean PIIINP levels were significantly higher than in controls (8.3±1.1 vs 3.3±0.2 ng/ml, p

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalEuropean Journal of Internal Medicine, Supplement
Volume4
Issue number1
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Medicine(all)
  • Internal Medicine

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