TY - JOUR
T1 - Serum amino-terminal propeptide of type III procollagen (PIIINP) levels in patients with acromegaly before and after pituitary adenomectomy
AU - Sartorio, A.
AU - Monzani, M.
AU - Conti, A.
AU - Casati, G.
AU - Faglia, G.
PY - 1993
Y1 - 1993
N2 - Growth hormone (GH) plays an important role on both bone and collagen metabolism via systemic insulin-like growth factors (IGF) production or directly by stimulating either the differentiation of precursor cells or the local production of growth factors. In this study we evaluated serum amino- terminal propeptide of type III procollagen (PIIINP) levels, specific and reliable marker of collagen synthesis, in a group of patients with acromegaly (4M, 3F, age range: 29-63 yrs) before and 2, 6 and 9 months after transnasosphenoidal pituitary adenomectomy. In active acromegaly (GH: 23.6±7.6 ng/ml, IGF-I: 140.5±18 nmol/L), mean PIIINP levels were significantly higher than in controls (8.3±1.1 vs 3.3±0.2 ng/ml, p
AB - Growth hormone (GH) plays an important role on both bone and collagen metabolism via systemic insulin-like growth factors (IGF) production or directly by stimulating either the differentiation of precursor cells or the local production of growth factors. In this study we evaluated serum amino- terminal propeptide of type III procollagen (PIIINP) levels, specific and reliable marker of collagen synthesis, in a group of patients with acromegaly (4M, 3F, age range: 29-63 yrs) before and 2, 6 and 9 months after transnasosphenoidal pituitary adenomectomy. In active acromegaly (GH: 23.6±7.6 ng/ml, IGF-I: 140.5±18 nmol/L), mean PIIINP levels were significantly higher than in controls (8.3±1.1 vs 3.3±0.2 ng/ml, p
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M3 - Article
AN - SCOPUS:0027438138
VL - 4
SP - 79
EP - 83
JO - European Journal of Internal Medicine, Supplement
JF - European Journal of Internal Medicine, Supplement
SN - 1121-8967
IS - 1
ER -