Serum amyloid A: A marker of adiposity-induced low-grade inflammation but not of metabolic status

Christine Poitou, Christiane Coussieu, Christine Rouault, Muriel Coupaye, Raffaella Cancello, Jean François Bedel, Madeleine Gouillon, Jean Luc Bouillot, Jean Michel Oppert, Arnaud Basdevant, Karine Clément

Research output: Contribution to journalArticle

Abstract

Objective: Adipocytes secrete a series of acute phase proteins including serum amyloid A (SAA); the link with metabolic status is unknown. We studied the variations of expression of the SAA gene in adipose and liver tissues and of SAA serum levels, as well as their relationships with metabolic features during weight loss. Research Methods and Procedures: Plasmatic variations of SAA, inflammatory markers (high sensitivity C-reactive protein, interleukin-6, fibrinogen, and orosomucoid), and adipokines (adiponectin, leptin) were studied in 60 morbidly obese patients before and after gastric surgery. For 10 subjects, SAA mRNA expression was measured at baseline in subcutaneous white adipose tissue (scWAT) and visceral white adipose tissue (vWAT) and in the liver. The evolution of SAA mRNA expression was also studied after surgery in scWAT. Results: SAA serum concentration displayed a significant reduction 3 months after surgery and remained stable beyond 6 months. mRNA expression of inducible SAA isoforms (SAA 1 and 2) in scWAT was higher than in vWAT (p = 0.01) and the liver (p <0.01) and correlated significantly with BMI, SAA, and high sensitivity C-reactive protein serum concentrations but not with metabolic markers (glucose, insulin, lipid parameters, adiponectin). SAA serum level and its variation during weight loss significantly correlated with adiposity markers (BMI and adipocyte volume, p <0.01) and inflammatory markers but not with variations of metabolic parameters. The variations of SAA expression in scWAT after surgery correlated with changes in BMI and SAA protein serum levels (p <0.05). Discussion: SAA can be considered as a marker of adiposity-induced low-grade inflammation but not of the metabolic status of obese subjects.

Original languageEnglish
Pages (from-to)309-318
Number of pages10
JournalObesity
Volume14
Issue number2
DOIs
Publication statusPublished - Feb 2006

Fingerprint

Serum Amyloid A Protein
Adiposity
Inflammation
White Adipose Tissue
Subcutaneous Fat
Serum
Intra-Abdominal Fat
Adiponectin
Adipocytes
C-Reactive Protein
Messenger RNA
Weight Loss
Liver
Orosomucoid
Adipokines
Acute-Phase Proteins
Leptin
Fibrinogen

Keywords

  • Adipose tissue
  • Inflammation
  • Insulin resistance
  • Serum amyloid A
  • Weight loss

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Poitou, C., Coussieu, C., Rouault, C., Coupaye, M., Cancello, R., Bedel, J. F., ... Clément, K. (2006). Serum amyloid A: A marker of adiposity-induced low-grade inflammation but not of metabolic status. Obesity, 14(2), 309-318. https://doi.org/10.1038/oby.2006.40

Serum amyloid A : A marker of adiposity-induced low-grade inflammation but not of metabolic status. / Poitou, Christine; Coussieu, Christiane; Rouault, Christine; Coupaye, Muriel; Cancello, Raffaella; Bedel, Jean François; Gouillon, Madeleine; Bouillot, Jean Luc; Oppert, Jean Michel; Basdevant, Arnaud; Clément, Karine.

In: Obesity, Vol. 14, No. 2, 02.2006, p. 309-318.

Research output: Contribution to journalArticle

Poitou, C, Coussieu, C, Rouault, C, Coupaye, M, Cancello, R, Bedel, JF, Gouillon, M, Bouillot, JL, Oppert, JM, Basdevant, A & Clément, K 2006, 'Serum amyloid A: A marker of adiposity-induced low-grade inflammation but not of metabolic status', Obesity, vol. 14, no. 2, pp. 309-318. https://doi.org/10.1038/oby.2006.40
Poitou, Christine ; Coussieu, Christiane ; Rouault, Christine ; Coupaye, Muriel ; Cancello, Raffaella ; Bedel, Jean François ; Gouillon, Madeleine ; Bouillot, Jean Luc ; Oppert, Jean Michel ; Basdevant, Arnaud ; Clément, Karine. / Serum amyloid A : A marker of adiposity-induced low-grade inflammation but not of metabolic status. In: Obesity. 2006 ; Vol. 14, No. 2. pp. 309-318.
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abstract = "Objective: Adipocytes secrete a series of acute phase proteins including serum amyloid A (SAA); the link with metabolic status is unknown. We studied the variations of expression of the SAA gene in adipose and liver tissues and of SAA serum levels, as well as their relationships with metabolic features during weight loss. Research Methods and Procedures: Plasmatic variations of SAA, inflammatory markers (high sensitivity C-reactive protein, interleukin-6, fibrinogen, and orosomucoid), and adipokines (adiponectin, leptin) were studied in 60 morbidly obese patients before and after gastric surgery. For 10 subjects, SAA mRNA expression was measured at baseline in subcutaneous white adipose tissue (scWAT) and visceral white adipose tissue (vWAT) and in the liver. The evolution of SAA mRNA expression was also studied after surgery in scWAT. Results: SAA serum concentration displayed a significant reduction 3 months after surgery and remained stable beyond 6 months. mRNA expression of inducible SAA isoforms (SAA 1 and 2) in scWAT was higher than in vWAT (p = 0.01) and the liver (p <0.01) and correlated significantly with BMI, SAA, and high sensitivity C-reactive protein serum concentrations but not with metabolic markers (glucose, insulin, lipid parameters, adiponectin). SAA serum level and its variation during weight loss significantly correlated with adiposity markers (BMI and adipocyte volume, p <0.01) and inflammatory markers but not with variations of metabolic parameters. The variations of SAA expression in scWAT after surgery correlated with changes in BMI and SAA protein serum levels (p <0.05). Discussion: SAA can be considered as a marker of adiposity-induced low-grade inflammation but not of the metabolic status of obese subjects.",
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