Abstract
Amyloid A (SAA) and procalcitonin (PCT) have been reported as useful indicators of inflammation. Our aim was to assess the utility of SAA and PCT in establishing the severity of acute pancreatitis in comparison to C- reactive protein (CRP): ~Thirty-one patients with acute pancreatitis enrolled within 24 hr from the onset of pain and 31 healthy subjects were studied. Nineteen patients had mild acute pancreatitis, and 12 had severe pancreatitis. Serum SAA, PCT, and CRP were measured in all subjects at admission and, in acute pancreatitis patients, during the following five days. ~Patients with acute pancreatitis had serum concentrations of SAA, PC~T, and CRP significantly higher (P <0.001) than those of healthy subjects during the entire study period. Using cutoff values ranging from 240 to 250 mg/liter for SAA, from 0.252 to 0.255 ng/ml for PCT, and from 12.8 to 12.9 mg/dl for CRP, the sensitivity (calculated on patients with severe pancreatitis), the specificity (calculated on patients with mild pancreatitis), and the efficiency (calculated as the percentage of correct classifications) were 76.8%, 69.3%, and 72.4% for SAA; 21.7%, 83.2%, and 58.2% for PCT; and 60.9%, 89.1%, and 77.6% for CRP. In conclusion, the sensitivity of SAA is significantly higher than that of PCT and CRP in assessing the severity of pancreatitis, whereas PCT and CRP had a specificity significantly higher than SAA. The accuracy and efficiency were similar for SAA and CRP, and both these markers had an accuracy and efficiency significantly higher than those of PCT.
| Original language | English |
|---|---|
| Pages (from-to) | 1072-1078 |
| Number of pages | 7 |
| Journal | Digestive Diseases and Sciences |
| Volume | 45 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- Acute pancreatitis
- Amyloid A
- C-reactive protein
- Procalcitonin
ASJC Scopus subject areas
- Gastroenterology
Cite this
Serum amyloid A, procalcitonin, and C-reactive protein in early assessment of severity of acute pancreatitis. / Pezzilli, Raffaele; D'Eril, Gian Vico Melzi; Morselli-Labate, Antonio Maria; Merlini, Gianpaolo; Barakat, Bahjat; Bosoni, Tiziana.
In: Digestive Diseases and Sciences, Vol. 45, No. 6, 2000, p. 1072-1078.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum amyloid A, procalcitonin, and C-reactive protein in early assessment of severity of acute pancreatitis
AU - Pezzilli, Raffaele
AU - D'Eril, Gian Vico Melzi
AU - Morselli-Labate, Antonio Maria
AU - Merlini, Gianpaolo
AU - Barakat, Bahjat
AU - Bosoni, Tiziana
PY - 2000
Y1 - 2000
N2 - Amyloid A (SAA) and procalcitonin (PCT) have been reported as useful indicators of inflammation. Our aim was to assess the utility of SAA and PCT in establishing the severity of acute pancreatitis in comparison to C- reactive protein (CRP): ~Thirty-one patients with acute pancreatitis enrolled within 24 hr from the onset of pain and 31 healthy subjects were studied. Nineteen patients had mild acute pancreatitis, and 12 had severe pancreatitis. Serum SAA, PCT, and CRP were measured in all subjects at admission and, in acute pancreatitis patients, during the following five days. ~Patients with acute pancreatitis had serum concentrations of SAA, PC~T, and CRP significantly higher (P <0.001) than those of healthy subjects during the entire study period. Using cutoff values ranging from 240 to 250 mg/liter for SAA, from 0.252 to 0.255 ng/ml for PCT, and from 12.8 to 12.9 mg/dl for CRP, the sensitivity (calculated on patients with severe pancreatitis), the specificity (calculated on patients with mild pancreatitis), and the efficiency (calculated as the percentage of correct classifications) were 76.8%, 69.3%, and 72.4% for SAA; 21.7%, 83.2%, and 58.2% for PCT; and 60.9%, 89.1%, and 77.6% for CRP. In conclusion, the sensitivity of SAA is significantly higher than that of PCT and CRP in assessing the severity of pancreatitis, whereas PCT and CRP had a specificity significantly higher than SAA. The accuracy and efficiency were similar for SAA and CRP, and both these markers had an accuracy and efficiency significantly higher than those of PCT.
AB - Amyloid A (SAA) and procalcitonin (PCT) have been reported as useful indicators of inflammation. Our aim was to assess the utility of SAA and PCT in establishing the severity of acute pancreatitis in comparison to C- reactive protein (CRP): ~Thirty-one patients with acute pancreatitis enrolled within 24 hr from the onset of pain and 31 healthy subjects were studied. Nineteen patients had mild acute pancreatitis, and 12 had severe pancreatitis. Serum SAA, PCT, and CRP were measured in all subjects at admission and, in acute pancreatitis patients, during the following five days. ~Patients with acute pancreatitis had serum concentrations of SAA, PC~T, and CRP significantly higher (P <0.001) than those of healthy subjects during the entire study period. Using cutoff values ranging from 240 to 250 mg/liter for SAA, from 0.252 to 0.255 ng/ml for PCT, and from 12.8 to 12.9 mg/dl for CRP, the sensitivity (calculated on patients with severe pancreatitis), the specificity (calculated on patients with mild pancreatitis), and the efficiency (calculated as the percentage of correct classifications) were 76.8%, 69.3%, and 72.4% for SAA; 21.7%, 83.2%, and 58.2% for PCT; and 60.9%, 89.1%, and 77.6% for CRP. In conclusion, the sensitivity of SAA is significantly higher than that of PCT and CRP in assessing the severity of pancreatitis, whereas PCT and CRP had a specificity significantly higher than SAA. The accuracy and efficiency were similar for SAA and CRP, and both these markers had an accuracy and efficiency significantly higher than those of PCT.
KW - Acute pancreatitis
KW - Amyloid A
KW - C-reactive protein
KW - Procalcitonin
UR - http://www.scopus.com/inward/record.url?scp=0034126750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034126750&partnerID=8YFLogxK
U2 - 10.1023/A:1005525329939
DO - 10.1023/A:1005525329939
M3 - Article
C2 - 10877218
AN - SCOPUS:0034126750
VL - 45
SP - 1072
EP - 1078
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 6
ER -