Serum and bile lipids in young women with radiolucent gallstones

A. Cavallini, C. Messa, V. Mangini, V. Argese, G. Misciagna, I. Giorgio

Research output: Contribution to journalArticle

Abstract

To investigate the relationship between blood and bile lipids, serum cholesterol, high density lipoprotein cholesterol, and triglycerides were correlated with cholesterol saturation index of bile in 21 women - 10 with radiolucent gallstones and 11 without stones. All of the women had regular menstrual cycles, were normolipidemic, and on a hospital diet. On the same morning, blood and the darkest duodenal bile were taken after cholecystokinin (CCK) stimulation. Standard laboratory procedures were used to analyze serum and bile lipids. We found: 1) statistically significant (t test, p <0.05) but only slight hypercholesterolemia (+12%) in patients with gallstones; 2) a negative correlation of serum cholesterol with cholesterol saturation index of bile, both in the control group (r = -0.654, p <0.05) and in gallstone patients (r = -0.665, p <0.05); 3) a correlation of high density lipoprotein cholesterol with cholesterol saturation index only in normal women (r = -0.619, p <0.05); 4) conversely, a correlation of triglycerides with the same index in only gallstone patients (r = 0.641, p <0.05). With the stepwise multiple regression analysis (independent variables: diagnosis of gallstones, serum cholesterol, HDL cholesterol, triglycerides; dependent variable: biliary cholesterol saturation index), only gallstone diagnosis and serum cholesterol influenced significantly (F test, p <0.05) the biliary cholesterol saturation index. These findings suggest that young women with radiolucent gallstones are slightly hypercholesterolemic, that in women both with and without gallstones there is a negative correlation between serum cholesterol and biliary cholesterol saturation, but women with gallstones have a higher cholesterol saturation index of the bile than women without gallstones with the same level of cholesterol in the blood.

Original languageEnglish
Pages (from-to)1279-1282
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume82
Issue number12
Publication statusPublished - 1987

Fingerprint

Gallstones
Bile
Cholesterol
Lipids
Serum
HDL Cholesterol
Triglycerides
Cholecystokinin
Menstrual Cycle
Hypercholesterolemia
Regression Analysis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cavallini, A., Messa, C., Mangini, V., Argese, V., Misciagna, G., & Giorgio, I. (1987). Serum and bile lipids in young women with radiolucent gallstones. American Journal of Gastroenterology, 82(12), 1279-1282.

Serum and bile lipids in young women with radiolucent gallstones. / Cavallini, A.; Messa, C.; Mangini, V.; Argese, V.; Misciagna, G.; Giorgio, I.

In: American Journal of Gastroenterology, Vol. 82, No. 12, 1987, p. 1279-1282.

Research output: Contribution to journalArticle

Cavallini, A, Messa, C, Mangini, V, Argese, V, Misciagna, G & Giorgio, I 1987, 'Serum and bile lipids in young women with radiolucent gallstones', American Journal of Gastroenterology, vol. 82, no. 12, pp. 1279-1282.
Cavallini A, Messa C, Mangini V, Argese V, Misciagna G, Giorgio I. Serum and bile lipids in young women with radiolucent gallstones. American Journal of Gastroenterology. 1987;82(12):1279-1282.
Cavallini, A. ; Messa, C. ; Mangini, V. ; Argese, V. ; Misciagna, G. ; Giorgio, I. / Serum and bile lipids in young women with radiolucent gallstones. In: American Journal of Gastroenterology. 1987 ; Vol. 82, No. 12. pp. 1279-1282.
@article{80193713b7e847a1a76f6e0fa6122195,
title = "Serum and bile lipids in young women with radiolucent gallstones",
abstract = "To investigate the relationship between blood and bile lipids, serum cholesterol, high density lipoprotein cholesterol, and triglycerides were correlated with cholesterol saturation index of bile in 21 women - 10 with radiolucent gallstones and 11 without stones. All of the women had regular menstrual cycles, were normolipidemic, and on a hospital diet. On the same morning, blood and the darkest duodenal bile were taken after cholecystokinin (CCK) stimulation. Standard laboratory procedures were used to analyze serum and bile lipids. We found: 1) statistically significant (t test, p <0.05) but only slight hypercholesterolemia (+12{\%}) in patients with gallstones; 2) a negative correlation of serum cholesterol with cholesterol saturation index of bile, both in the control group (r = -0.654, p <0.05) and in gallstone patients (r = -0.665, p <0.05); 3) a correlation of high density lipoprotein cholesterol with cholesterol saturation index only in normal women (r = -0.619, p <0.05); 4) conversely, a correlation of triglycerides with the same index in only gallstone patients (r = 0.641, p <0.05). With the stepwise multiple regression analysis (independent variables: diagnosis of gallstones, serum cholesterol, HDL cholesterol, triglycerides; dependent variable: biliary cholesterol saturation index), only gallstone diagnosis and serum cholesterol influenced significantly (F test, p <0.05) the biliary cholesterol saturation index. These findings suggest that young women with radiolucent gallstones are slightly hypercholesterolemic, that in women both with and without gallstones there is a negative correlation between serum cholesterol and biliary cholesterol saturation, but women with gallstones have a higher cholesterol saturation index of the bile than women without gallstones with the same level of cholesterol in the blood.",
author = "A. Cavallini and C. Messa and V. Mangini and V. Argese and G. Misciagna and I. Giorgio",
year = "1987",
language = "English",
volume = "82",
pages = "1279--1282",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - Serum and bile lipids in young women with radiolucent gallstones

AU - Cavallini, A.

AU - Messa, C.

AU - Mangini, V.

AU - Argese, V.

AU - Misciagna, G.

AU - Giorgio, I.

PY - 1987

Y1 - 1987

N2 - To investigate the relationship between blood and bile lipids, serum cholesterol, high density lipoprotein cholesterol, and triglycerides were correlated with cholesterol saturation index of bile in 21 women - 10 with radiolucent gallstones and 11 without stones. All of the women had regular menstrual cycles, were normolipidemic, and on a hospital diet. On the same morning, blood and the darkest duodenal bile were taken after cholecystokinin (CCK) stimulation. Standard laboratory procedures were used to analyze serum and bile lipids. We found: 1) statistically significant (t test, p <0.05) but only slight hypercholesterolemia (+12%) in patients with gallstones; 2) a negative correlation of serum cholesterol with cholesterol saturation index of bile, both in the control group (r = -0.654, p <0.05) and in gallstone patients (r = -0.665, p <0.05); 3) a correlation of high density lipoprotein cholesterol with cholesterol saturation index only in normal women (r = -0.619, p <0.05); 4) conversely, a correlation of triglycerides with the same index in only gallstone patients (r = 0.641, p <0.05). With the stepwise multiple regression analysis (independent variables: diagnosis of gallstones, serum cholesterol, HDL cholesterol, triglycerides; dependent variable: biliary cholesterol saturation index), only gallstone diagnosis and serum cholesterol influenced significantly (F test, p <0.05) the biliary cholesterol saturation index. These findings suggest that young women with radiolucent gallstones are slightly hypercholesterolemic, that in women both with and without gallstones there is a negative correlation between serum cholesterol and biliary cholesterol saturation, but women with gallstones have a higher cholesterol saturation index of the bile than women without gallstones with the same level of cholesterol in the blood.

AB - To investigate the relationship between blood and bile lipids, serum cholesterol, high density lipoprotein cholesterol, and triglycerides were correlated with cholesterol saturation index of bile in 21 women - 10 with radiolucent gallstones and 11 without stones. All of the women had regular menstrual cycles, were normolipidemic, and on a hospital diet. On the same morning, blood and the darkest duodenal bile were taken after cholecystokinin (CCK) stimulation. Standard laboratory procedures were used to analyze serum and bile lipids. We found: 1) statistically significant (t test, p <0.05) but only slight hypercholesterolemia (+12%) in patients with gallstones; 2) a negative correlation of serum cholesterol with cholesterol saturation index of bile, both in the control group (r = -0.654, p <0.05) and in gallstone patients (r = -0.665, p <0.05); 3) a correlation of high density lipoprotein cholesterol with cholesterol saturation index only in normal women (r = -0.619, p <0.05); 4) conversely, a correlation of triglycerides with the same index in only gallstone patients (r = 0.641, p <0.05). With the stepwise multiple regression analysis (independent variables: diagnosis of gallstones, serum cholesterol, HDL cholesterol, triglycerides; dependent variable: biliary cholesterol saturation index), only gallstone diagnosis and serum cholesterol influenced significantly (F test, p <0.05) the biliary cholesterol saturation index. These findings suggest that young women with radiolucent gallstones are slightly hypercholesterolemic, that in women both with and without gallstones there is a negative correlation between serum cholesterol and biliary cholesterol saturation, but women with gallstones have a higher cholesterol saturation index of the bile than women without gallstones with the same level of cholesterol in the blood.

UR - http://www.scopus.com/inward/record.url?scp=0023605061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023605061&partnerID=8YFLogxK

M3 - Article

C2 - 3687905

AN - SCOPUS:0023605061

VL - 82

SP - 1279

EP - 1282

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 12

ER -