Serum and cerebrospinal fluid herpes simplex virus type 1 immunoglobulin G and M titers in four cases of herpes simplex encephalitis.

M. Ceroni, C. Camana, D. M. Franciotta, G. Bolelli, M. G. Revello, G. Gerna, F. Savoldi

Research output: Contribution to journalArticlepeer-review

Abstract

Herpes simplex virus type 1 (HSV-1) IgG and IgM ELISA titers were serially determined in serum and cerebrospinal fluid (CSF) samples from 4 patients with HSV-1 encephalitis during a follow-up period of 1-26 months. In 3 out of 4 patients HSV-1 IgM titers raised in CSF during the acute phase of disease, thus allowing differentiation between primary and reactivated forms of HSV-1 encephalitis. HSV-1 IgG titers showed a sharp elevation earlier in serum than in CSF. Specific IgG index documented a large intrathecal production of HSV-1 IgG and their persistence 2 years following clinical onset. The initial trend of serum and CSF specific IgG titer represents a reliable tool for a retrospective diagnosis of HSV-1 encephalitis.

Original languageEnglish
Pages (from-to)1215-1222
Number of pages8
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume66
Issue number12
Publication statusPublished - Dec 1990

ASJC Scopus subject areas

  • Medicine(all)

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