Serum and cerebrospinal fluid human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) in intracranial germ cell tumors

E. Seregni, M. Massimino, S. Nerini Molteni, F. Pallotti, B. Van Der Hiel, G. Cefalo, F. Spreafico, F. Fossati, Emilio Bombardieri

Research output: Contribution to journalArticle

Abstract

We report a retrospective study on serum and cerebrospinal fluid (CSF) alpha-fetoprotein (AFP) and β-human chorionic gonadotropin (βhCG) determination in a series of 30 patients bearing intracranial germ cell tumors. At diagnosis five patients had high serum and CSF AFP levels. No patient had positive serum AFP and negative CSF AFP or vice versa. Twelve of 30 patients had serum βhCG levels above 5 ml/U/mL, eight had high βhCG only in CSF, and ten were completely negative. During treatment and follow-up both markers were accurate indicators of the response to therapy, decreasing rapidly and often becoming normal already after the first phase of treatment. We conclude that these two markers, and mostly βhCG, may be useful in the diagnosis and monitoring of the response to therapy of patients with intracranial germ cell tumors.

Original languageEnglish
Pages (from-to)112-118
Number of pages7
JournalInternational Journal of Biological Markers
Volume17
Issue number2
Publication statusPublished - 2002

Keywords

  • Alpha-fetoprotein (AFP)
  • Cerebrospinal fluid (CSF)
  • Human chorionic gonadotropin (hCG)
  • Intracranial germ cell tumors (IGCT)

ASJC Scopus subject areas

  • Biochemistry
  • Immunology

Fingerprint Dive into the research topics of 'Serum and cerebrospinal fluid human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) in intracranial germ cell tumors'. Together they form a unique fingerprint.

  • Cite this