Abstract
Thiamphenicol is an analogue of chloramphenicol and is characterised by a broad spectrum of action. In this study, serum and lung levels of thiamphenicol (TAP) were studied in infected guinea pigs after the administration of thiamphenicol glycinate N-acetylcysteinate (TGA). Animals received a single dose of TGA (15 mg/kg, subcutaneously) immediately after intra-tracheal infection with Haemophilus influenzae (about 107 CFU/animal). Serum and lung concentrations of TAP were determined at 0, 1, 3, 6, 12 and 24 h after drug administration by means of HPLC. TAP serum levels were elevated at 1 h and remained detectable for 24 h after drug administration. Tissue lung levels were comparable to peak serum concentrations but remained higher and decreased more slowly than serum concentrations. Copyright (C) 2000 Elsevier Science B.V.
Original language | English |
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Pages (from-to) | 301-303 |
Number of pages | 3 |
Journal | International Journal of Antimicrobial Agents |
Volume | 13 |
Issue number | 4 |
DOIs | |
Publication status | Published - Feb 2000 |
Keywords
- Guinea pigs
- N-acetylcysteine
- Thiamphenicol
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Microbiology
- Parasitology
- Virology
- Immunology and Allergy
- Infectious Diseases