Serum and lung levels of thiamphenicol after administration of its glycinate N-acetylcysteinate ester in experimentally infected guinea pigs

Lorenzo Drago, Elena De Vecchi, Maria Cristina Fassina, Barbara Mombelli, Maria Rita Gismondo

Research output: Contribution to journalArticlepeer-review

Abstract

Thiamphenicol is an analogue of chloramphenicol and is characterised by a broad spectrum of action. In this study, serum and lung levels of thiamphenicol (TAP) were studied in infected guinea pigs after the administration of thiamphenicol glycinate N-acetylcysteinate (TGA). Animals received a single dose of TGA (15 mg/kg, subcutaneously) immediately after intra-tracheal infection with Haemophilus influenzae (about 107 CFU/animal). Serum and lung concentrations of TAP were determined at 0, 1, 3, 6, 12 and 24 h after drug administration by means of HPLC. TAP serum levels were elevated at 1 h and remained detectable for 24 h after drug administration. Tissue lung levels were comparable to peak serum concentrations but remained higher and decreased more slowly than serum concentrations. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)301-303
Number of pages3
JournalInternational Journal of Antimicrobial Agents
Volume13
Issue number4
DOIs
Publication statusPublished - Feb 2000

Keywords

  • Guinea pigs
  • N-acetylcysteine
  • Thiamphenicol

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

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