Serum and placenta levels of cholestasis enzymes in pregnancy

A. Francavilla, F. Pansini, E. Altomare

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In the present report cholestasis enzymes have been observed during pregnancy, with study made of the three most important enzymes of cholestasis in serum: alkaline phosphatase (PHA), leucine amine peptidase (LAP), γ-glutamyl transpeptidase (γ-GT). In accordance with previous data, alkaline phosphatase and leucine amine peptidase levels were found to increase during the 3rd trimester of pregnancy, remaining elevated during the first week of puerperium, while no increase was observed in γ-glutamyl transpeptidase in patients during pregnancy. The above changes in serum concentration of enzyme activity were all statistically calculated. This study of cholestasis enzymes indicates the presence of high concentrations, of PHA and LAP placenta tissue, with an absence of γ-GT. On the basis of these results, it is suggested that value of γ-GT in serum is the only index of cholestasis liver during pregnancy.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalClinical and Experimental Obstetrics and Gynecology
Issue number1-4
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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