Serum and placenta levels of cholestasis enzymes in pregnancy

A. Francavilla, F. Pansini, E. Altomare

Research output: Contribution to journalArticle

Abstract

In the present report cholestasis enzymes have been observed during pregnancy, with study made of the three most important enzymes of cholestasis in serum: alkaline phosphatase (PHA), leucine amine peptidase (LAP), γ-glutamyl transpeptidase (γ-GT). In accordance with previous data, alkaline phosphatase and leucine amine peptidase levels were found to increase during the 3rd trimester of pregnancy, remaining elevated during the first week of puerperium, while no increase was observed in γ-glutamyl transpeptidase in patients during pregnancy. The above changes in serum concentration of enzyme activity were all statistically calculated. This study of cholestasis enzymes indicates the presence of high concentrations, of PHA and LAP placenta tissue, with an absence of γ-GT. On the basis of these results, it is suggested that value of γ-GT in serum is the only index of cholestasis liver during pregnancy.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalClinical and Experimental Obstetrics and Gynecology
Volume3
Issue number1-4
Publication statusPublished - 1976

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Cholestasis
Placenta
Leucine
Amines
Pregnancy
Peptide Hydrolases
gamma-Glutamyltransferase
Enzymes
Serum
Alkaline Phosphatase
Pregnancy Trimesters
Phosphoric Monoester Hydrolases
Postpartum Period
Liver

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Serum and placenta levels of cholestasis enzymes in pregnancy. / Francavilla, A.; Pansini, F.; Altomare, E.

In: Clinical and Experimental Obstetrics and Gynecology, Vol. 3, No. 1-4, 1976, p. 62-66.

Research output: Contribution to journalArticle

Francavilla, A, Pansini, F & Altomare, E 1976, 'Serum and placenta levels of cholestasis enzymes in pregnancy', Clinical and Experimental Obstetrics and Gynecology, vol. 3, no. 1-4, pp. 62-66.
Francavilla, A. ; Pansini, F. ; Altomare, E. / Serum and placenta levels of cholestasis enzymes in pregnancy. In: Clinical and Experimental Obstetrics and Gynecology. 1976 ; Vol. 3, No. 1-4. pp. 62-66.
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