Serum and plasma BDNF levels in major depression: A replication study and meta-analyses

Luisella Bocchio-Chiavetto, Vincenzo Bagnardi, Roberta Zanardini, Raffaella Molteni, Maria Gabriela Nielsen, Anna Placentino, Caterina Giovannini, Luciana Rillosi, Mariacarla Ventriglia, Marco A. Riva, Massimo Gennarelli

Research output: Contribution to journalArticlepeer-review


Objectives. Alterations of BDNF signalling in major depression (MD) are supported by studies demonstrating decreased levels of the neurotrophin serum and plasma content in MD patients. We conducted a replication study and we performed two meta-analyses on studies analysing serum and plasma BDNF levels in MD patients. Methods. The samples were composed by 489 patients/483 controls for the meta-analysis on serum and by 161 patients/211 controls for that on plasma levels. We performed also subgroup analyses to examine whether the decrease in BDNF levels in MD was influenced by gender. Results. In the replication study we found decreased serum BDNF levels in MD patients (P

Original languageEnglish
Pages (from-to)763-773
Number of pages11
JournalWorld Journal of Biological Psychiatry
Issue number6
Publication statusPublished - Sep 2010


  • BDNF
  • Gender
  • Major depression
  • Meta-analysis

ASJC Scopus subject areas

  • Biological Psychiatry
  • Psychiatry and Mental health


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