Abstract
Objective: There is consistent evidence demonstrating that laparoscopic removal of benign ovarian cysts significantly damages the ovarian reserve. In contrast, the pre-operative impact of these cysts on the ovarian reserve is yet controversial. To elucidate this aspect, we set up a cross-sectional study in reproductive age women with and without benign ovarian cysts. Study design: Inclusion criteria were as follow: (1) Age 18-40 years, (2) regular menstrual cycles, (3) Indication to laparoscopic surgery. Eligible women donated a blood sample for anti-Mullerian hormone (AMH) testing. Women who were diagnosed at surgery with concomitant endometriotic and non-endometriotic ovarian cysts, deep infiltrating peritoneal endometriosis or malignancies were subsequently excluded. Results: Diagnoses of the included women were as follows: ovarian endometriomas (n = 122), non-endometriotic ovarian cysts (n = 50) and non-ovarian diagnoses (n = 113). Serum AMH in the three groups did not significantly differ. The median (Interquartile range-IQR) was 1.8 (0.8-3.1), 2.0 (0.8-3.9) and 1.9 (0.9-3.3) ng/ml, respectively (p = 0.60). The analyses were repeated grouping women into those with bilateral cysts (n = 54), unilateral cysts (n = 118) and intact gonads (n = 113). Women with bilateral lesions were found to have significantly lower levels of serum AMH. The median (IQR) serum AMH in the three groups was 1.3 (0.5-2.5), 2.0 (1.1-3.6) and 1.9 (0.9-3.3) ng/ml, respectively (p = 0.019). We failed to demonstrate any correlation between serum AMH and the dimension of the ovarian cysts. Conclusions: Serum AMH is lower in women with bilateral ovarian cysts and this does not appear to be related to the histology or dimension of the lesions.
| Original language | English |
|---|---|
| Pages (from-to) | 142-147 |
| Number of pages | 6 |
| Journal | European Journal of Obstetrics and Gynecology and Reproductive Biology |
| Volume | 180 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2015 |
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Keywords
- AMH
- Endometriomas
- Ovarian cysts
- Ovarian reserve
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Reproductive Medicine
Cite this
Serum anti-mullerian hormone in reproductive aged women with benign ovarian cysts. / Somigliana, Edgardo; Marchese, Maria Antonietta; Frattaruolo, Maria Pina; Berlanda, Nicola; Fedele, Luigi; Vercellini, Paolo.
In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 180, No. 1, 2015, p. 142-147.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum anti-mullerian hormone in reproductive aged women with benign ovarian cysts
AU - Somigliana, Edgardo
AU - Marchese, Maria Antonietta
AU - Frattaruolo, Maria Pina
AU - Berlanda, Nicola
AU - Fedele, Luigi
AU - Vercellini, Paolo
PY - 2015
Y1 - 2015
N2 - Objective: There is consistent evidence demonstrating that laparoscopic removal of benign ovarian cysts significantly damages the ovarian reserve. In contrast, the pre-operative impact of these cysts on the ovarian reserve is yet controversial. To elucidate this aspect, we set up a cross-sectional study in reproductive age women with and without benign ovarian cysts. Study design: Inclusion criteria were as follow: (1) Age 18-40 years, (2) regular menstrual cycles, (3) Indication to laparoscopic surgery. Eligible women donated a blood sample for anti-Mullerian hormone (AMH) testing. Women who were diagnosed at surgery with concomitant endometriotic and non-endometriotic ovarian cysts, deep infiltrating peritoneal endometriosis or malignancies were subsequently excluded. Results: Diagnoses of the included women were as follows: ovarian endometriomas (n = 122), non-endometriotic ovarian cysts (n = 50) and non-ovarian diagnoses (n = 113). Serum AMH in the three groups did not significantly differ. The median (Interquartile range-IQR) was 1.8 (0.8-3.1), 2.0 (0.8-3.9) and 1.9 (0.9-3.3) ng/ml, respectively (p = 0.60). The analyses were repeated grouping women into those with bilateral cysts (n = 54), unilateral cysts (n = 118) and intact gonads (n = 113). Women with bilateral lesions were found to have significantly lower levels of serum AMH. The median (IQR) serum AMH in the three groups was 1.3 (0.5-2.5), 2.0 (1.1-3.6) and 1.9 (0.9-3.3) ng/ml, respectively (p = 0.019). We failed to demonstrate any correlation between serum AMH and the dimension of the ovarian cysts. Conclusions: Serum AMH is lower in women with bilateral ovarian cysts and this does not appear to be related to the histology or dimension of the lesions.
AB - Objective: There is consistent evidence demonstrating that laparoscopic removal of benign ovarian cysts significantly damages the ovarian reserve. In contrast, the pre-operative impact of these cysts on the ovarian reserve is yet controversial. To elucidate this aspect, we set up a cross-sectional study in reproductive age women with and without benign ovarian cysts. Study design: Inclusion criteria were as follow: (1) Age 18-40 years, (2) regular menstrual cycles, (3) Indication to laparoscopic surgery. Eligible women donated a blood sample for anti-Mullerian hormone (AMH) testing. Women who were diagnosed at surgery with concomitant endometriotic and non-endometriotic ovarian cysts, deep infiltrating peritoneal endometriosis or malignancies were subsequently excluded. Results: Diagnoses of the included women were as follows: ovarian endometriomas (n = 122), non-endometriotic ovarian cysts (n = 50) and non-ovarian diagnoses (n = 113). Serum AMH in the three groups did not significantly differ. The median (Interquartile range-IQR) was 1.8 (0.8-3.1), 2.0 (0.8-3.9) and 1.9 (0.9-3.3) ng/ml, respectively (p = 0.60). The analyses were repeated grouping women into those with bilateral cysts (n = 54), unilateral cysts (n = 118) and intact gonads (n = 113). Women with bilateral lesions were found to have significantly lower levels of serum AMH. The median (IQR) serum AMH in the three groups was 1.3 (0.5-2.5), 2.0 (1.1-3.6) and 1.9 (0.9-3.3) ng/ml, respectively (p = 0.019). We failed to demonstrate any correlation between serum AMH and the dimension of the ovarian cysts. Conclusions: Serum AMH is lower in women with bilateral ovarian cysts and this does not appear to be related to the histology or dimension of the lesions.
KW - AMH
KW - Endometriomas
KW - Ovarian cysts
KW - Ovarian reserve
UR - http://www.scopus.com/inward/record.url?scp=84930928629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930928629&partnerID=8YFLogxK
U2 - 10.1016/j.ejogrb.2014.06.009
DO - 10.1016/j.ejogrb.2014.06.009
M3 - Article
C2 - 25009087
AN - SCOPUS:84930928629
VL - 180
SP - 142
EP - 147
JO - European Journal of Obstetrics, Gynecology and Reproductive Biology
JF - European Journal of Obstetrics, Gynecology and Reproductive Biology
SN - 0028-2243
IS - 1
ER -