Serum anti-tissue transglutaminase antibodies detected during febrile illness may not be produced by the intestinal mucosa

Luigina De Leo, Sara Quaglia, Fabiana Ziberna, Serena Vatta, Stefano Martelossi, Massimo Maschio, Tarcisio Not

Research output: Contribution to journalArticlepeer-review

Abstract

Anti-transglutaminase antibodies are the diagnostic marker of celiac disease, and are considered to be synthesized only by intestinal B-lymphocytes. During an infectious disease, these antibodies are transiently detected in serum. We show that these infection-triggered antibodies may not originate in the intestinal mucosa and are not an indication of celiac disease.

Original languageEnglish
Pages (from-to)761-763
Number of pages3
JournalJournal of Pediatrics
Volume166
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

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