Serum antibodies to Purkinje cells and dorsal root ganglia neurons in sensory neuronopathy without malignancy

R. Nemni, M. Camerlingo, R. Fazio, L. Casto, A. Quattrini, D. Mamoli, I. Lorenzetti, N. Canal, A. Mamoli

Research output: Contribution to journalArticle

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Abstract

Anti-Purkinje cell antibodies (APCA), believed to be markers of paraneoplastic cerebellar degeneration in females, have been identified in the serum of 3 men with subacute sensory neuronopathies and no evidence of tumors 5 years after the onset of the neurological signs. By indirect immunohistochemistry on sections of rat cerebellum and dorsal root ganglia, the patients' IgG bound to the cytoplasms of both Purkinje cells and dorsal root ganglia neurons. By western blot analysis on whole human cerebellum and whole human dorsal root ganglia homogenates, the IgG from 2 patients bound to a 62-kd protein in both homogenates and the IgG from 1 patient bound to a 110-kd protein in the cerebellum homogenate only. Yo autoantibody test was negative in all patients. Our study provides evidence that non-anti-Yo APCA may be associated with subacute sensory neuronopathies and are not necessarily markers of an underlying tumor. The previously described anti-Yo APCA has only occurred in females with cancer.

Original languageEnglish
Pages (from-to)848-854
Number of pages7
JournalAnnals of Neurology
Volume34
Issue number6
DOIs
Publication statusPublished - 1993

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Purkinje Cells
Spinal Ganglia
Sensory Receptor Cells
Cerebellum
Antibodies
Immunoglobulin G
Serum
Neoplasms
Paraneoplastic Cerebellar Degeneration
Tumor Biomarkers
Autoantibodies
Cytoplasm
Proteins
Western Blotting
Immunohistochemistry
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Serum antibodies to Purkinje cells and dorsal root ganglia neurons in sensory neuronopathy without malignancy. / Nemni, R.; Camerlingo, M.; Fazio, R.; Casto, L.; Quattrini, A.; Mamoli, D.; Lorenzetti, I.; Canal, N.; Mamoli, A.

In: Annals of Neurology, Vol. 34, No. 6, 1993, p. 848-854.

Research output: Contribution to journalArticle

Nemni, R. ; Camerlingo, M. ; Fazio, R. ; Casto, L. ; Quattrini, A. ; Mamoli, D. ; Lorenzetti, I. ; Canal, N. ; Mamoli, A. / Serum antibodies to Purkinje cells and dorsal root ganglia neurons in sensory neuronopathy without malignancy. In: Annals of Neurology. 1993 ; Vol. 34, No. 6. pp. 848-854.
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AU - Quattrini, A.

AU - Mamoli, D.

AU - Lorenzetti, I.

AU - Canal, N.

AU - Mamoli, A.

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