Serum B-Type Natriuretic Peptide is Affected by Neoplastic Edema in Patients with a Brain Tumor

Francesco Ruggieri, Alice Noris, Luigi Beretta, Pietro Mortini, Marco Gemma

Research output: Contribution to journalArticle

Abstract

Objective: A positive correlation between serum B-type natriuretic peptide levels and the amount of dislodgement of intracranial structures (mass effect) produced by brain tumors has been demonstrated previously. The aim of our prospective observational study was to evaluate a possible relationship between serum B-type natriuretic peptide levels and the amount of neoplastic edema in patients affected by brain tumor. Methods: We prospectively studied 110 patients with a supratentorial brain tumor. Serum N-terminal-pro B-type natriuretic peptide was measured and brain magnetic resonance images were analyzed to discriminate between neoplastic tissue and perilesional edema. A multivariate linear regression model predictive for serum N-terminal-pro B-type natriuretic peptide levels was generated. Results: The radiologic diagnoses were meningioma in 45 patients (40.9%), glioma in 33 (30%), and metastasis in 32 (29.1%). A mass effect was present in 29 (26.4%) patients. Serum N-terminal-pro B-type natriuretic peptide was 125.61 ± 174.14 pg/mL (median 60 pg/mL, interquartile range 28-139 pg/mL). Four variables were entered into a multivariate linear regression model predictive for serum N-terminal-pro B-type natriuretic peptide values: age, neoplastic edema volume, metastatic lesion, and the presence of a mass effect (whole model P <0.0001; R2 = 0.5555; adjusted R2 = 0.5294). Conclusions: Our data demonstrate that serum B-type natriuretic peptide levels are positively correlated to neoplastic brain edema in patients with a brain tumor and suggest a possible cerebral source for this phenomenon.
Original languageEnglish
Pages (from-to)193 - 196
Number of pages4
JournalWorld Neurosurgery
Volume85
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Brain Natriuretic Peptide
Brain Neoplasms
Edema
Serum
Linear Models
Supratentorial Neoplasms
Brain Edema
Meningioma
Glioma
Observational Studies
Magnetic Resonance Spectroscopy
Prospective Studies
Neoplasm Metastasis
Brain

Keywords

  • Brain edema
  • Brain neoplasm
  • Intracranial hypertension
  • Magnetic resonance imaging
  • Natriuretic peptide in the brain

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Serum B-Type Natriuretic Peptide is Affected by Neoplastic Edema in Patients with a Brain Tumor. / Ruggieri, Francesco; Noris, Alice; Beretta, Luigi; Mortini, Pietro; Gemma, Marco.

In: World Neurosurgery, Vol. 85, 01.01.2016, p. 193 - 196.

Research output: Contribution to journalArticle

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