Serum beta2-microglobulin levels and p24 antigen, lymphocyte depletion and disease progression in human immunodeficiency virus infection

R. Alfieri, A. Chirianni, T. Mancino, P. Remondelli, P. Russo, G. Liuzzi, R. Della Morte, N. Staiano

Research output: Contribution to journalArticle

Abstract

Abnormally elevated serum beta2-microglobulin levels have been associated with progression of human immunodeficiency virus disease. In this study we have analyzed the relationship between serum beta2-microglobulin levels of patients at different stages of the disease and serological and immunological parameters commonly used for monitoring the infection. The investigation was performed on 150 patients and 30 controls during the period from March 1989 to March 1990. At that time, 30 patients had the acquired immunodeficiency syndrome or its related complex and 120 had persistent generalized lymphadenopathy or were asymptomatic. Thirty-nine antibody-negative subjects, belonging to a high-risk group for the acquired immunodeficiency syndrome, were used as controls. All patients had normal renal function. There was a significant relationship between increased serum beta2-microglobulin levels and the presence of p24 antigen, a decrease in the total number of lymphocytes (≤1500/mm3) and a decrease in CD4+ T lymphocytes (≤200/mm3). No significant relationship between serum beta2-microglobulin levels and CD3+ T lymphocytes was found.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
JournalInternational Journal of Clinical & Laboratory Research
Volume22
Issue number1-4
DOIs
Publication statusPublished - Mar 1992

Keywords

  • Beta-microglobulin
  • CD4 T cells
  • Human immunodeficiency virus infection
  • Lymphocytes
  • p24 antigen

ASJC Scopus subject areas

  • Clinical Biochemistry

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