TY - JOUR
T1 - Serum bilirubin level is inversely associated with nonalcoholic steatohepatitis in children
AU - Puri, Kanika
AU - Nobili, Valerio
AU - Melville, Katherine
AU - Corte, Claudia D.
AU - Sartorelli, Maria R.
AU - Lopez, Rocio
AU - Feldstein, Ariel E.
AU - Alkhouri, Naim
PY - 2013/7
Y1 - 2013/7
N2 - OBJECTIVES: Oxidative stress has been implicated in the development of nonalcoholic fatty liver disease (NAFLD) and progression to the more severe form, nonalcoholic steatohepatitis (NASH), in children. We aimed to study the clinical correlation between bilirubin, a potent endogenous antioxidant with cytoprotective properties, and histopathological findings in pediatric patients with NAFLD. METHODS: We included consecutive children with biopsy-proven NAFLD and obtained demographic, clinical, and histopathological data. We performed logistic regression analysis to assess the clinical factors associated with the histological features of NASH or fibrosis. RESULTS: From a total of 302 biopsies, 67% (203) had evidence of NASH, whereas 64.2% had some degree of fibrosis (stage 1 in 51%, stage 2 in 6.3%, and stage 3 in 6.6%). Mean total bilirubin was significantly lower in the NASH group compared with the non-NASH group (0.65±0.24 vs 0.73±0.22 mg/dL, P=0.007). Higher total bilirubin levels were negatively correlated with the presence of steatosis and the NAFLD activity score (P
AB - OBJECTIVES: Oxidative stress has been implicated in the development of nonalcoholic fatty liver disease (NAFLD) and progression to the more severe form, nonalcoholic steatohepatitis (NASH), in children. We aimed to study the clinical correlation between bilirubin, a potent endogenous antioxidant with cytoprotective properties, and histopathological findings in pediatric patients with NAFLD. METHODS: We included consecutive children with biopsy-proven NAFLD and obtained demographic, clinical, and histopathological data. We performed logistic regression analysis to assess the clinical factors associated with the histological features of NASH or fibrosis. RESULTS: From a total of 302 biopsies, 67% (203) had evidence of NASH, whereas 64.2% had some degree of fibrosis (stage 1 in 51%, stage 2 in 6.3%, and stage 3 in 6.6%). Mean total bilirubin was significantly lower in the NASH group compared with the non-NASH group (0.65±0.24 vs 0.73±0.22 mg/dL, P=0.007). Higher total bilirubin levels were negatively correlated with the presence of steatosis and the NAFLD activity score (P
KW - Antioxidant
KW - Bilirubin
KW - Children
KW - Histology
KW - Nonalcoholic fatty liver disease
KW - Nonalcoholic steatohepatitis
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UR - http://www.scopus.com/inward/citedby.url?scp=84879889434&partnerID=8YFLogxK
U2 - 10.1097/MPG.0b013e318291fefe
DO - 10.1097/MPG.0b013e318291fefe
M3 - Article
C2 - 23518490
AN - SCOPUS:84879889434
VL - 57
SP - 114
EP - 118
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
SN - 0277-2116
IS - 1
ER -