Serum bone-Gla protein (BGP) and carboxyterminal cross-linked telopeptide of type I collagen (ICTP) levels in patients with primary hyperparathyroidism before and after surgery

A. Sartorio, A. Conti, M. Monzani, G. Faglia

Research output: Contribution to journalArticle

Abstract

The accurate biochemical evaluation of bone turnover is often prevented by the lack of specific and reliable markers of bone formation and especially of bone resorption. In this study, serum bone Gla-protein (BGP), marker of osteoblastic function, and serum carboxyterminal telopeptide of type I collagen (ICTP), index of bone resorption, were evaluated in 6 patients with primary hyperparathyroidism before, 10 days and 3 months after surgery. Mean baseline BGP (25.0±3.4 ng/ml) and ICTP (5.7±0.5 ng/ml) levels were significantly higher than in normal subjects. After parathyroidectomy, serum BGP and ICTP levels promptly decreased (at 10th day, BGP: 14.7±2.5 ng/ml; ICTP: 3.8±0.2 ng/ml), but remained significantly higher than those recorded in controls. Three months after surgery, serum ICTP levels normalized, while BGP levels remained significantly higher than in normals. In conclusion, our data show that serial determinations of serum BGP and of ICTP levels may be useful in monitoring the course of primary hyperparathyroidism.

Original languageEnglish
Pages (from-to)251-254
Number of pages4
JournalEuropean Journal of Internal Medicine
Volume4
Issue number3
Publication statusPublished - 1993

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Primary Hyperparathyroidism
Osteocalcin
Collagen Type I
Blood Proteins
Bone Resorption
Parathyroidectomy
Bone Remodeling
Osteogenesis
Serum

ASJC Scopus subject areas

  • Medicine(all)
  • Internal Medicine

Cite this

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title = "Serum bone-Gla protein (BGP) and carboxyterminal cross-linked telopeptide of type I collagen (ICTP) levels in patients with primary hyperparathyroidism before and after surgery",
abstract = "The accurate biochemical evaluation of bone turnover is often prevented by the lack of specific and reliable markers of bone formation and especially of bone resorption. In this study, serum bone Gla-protein (BGP), marker of osteoblastic function, and serum carboxyterminal telopeptide of type I collagen (ICTP), index of bone resorption, were evaluated in 6 patients with primary hyperparathyroidism before, 10 days and 3 months after surgery. Mean baseline BGP (25.0±3.4 ng/ml) and ICTP (5.7±0.5 ng/ml) levels were significantly higher than in normal subjects. After parathyroidectomy, serum BGP and ICTP levels promptly decreased (at 10th day, BGP: 14.7±2.5 ng/ml; ICTP: 3.8±0.2 ng/ml), but remained significantly higher than those recorded in controls. Three months after surgery, serum ICTP levels normalized, while BGP levels remained significantly higher than in normals. In conclusion, our data show that serial determinations of serum BGP and of ICTP levels may be useful in monitoring the course of primary hyperparathyroidism.",
author = "A. Sartorio and A. Conti and M. Monzani and G. Faglia",
year = "1993",
language = "English",
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AU - Sartorio, A.

AU - Conti, A.

AU - Monzani, M.

AU - Faglia, G.

PY - 1993

Y1 - 1993

N2 - The accurate biochemical evaluation of bone turnover is often prevented by the lack of specific and reliable markers of bone formation and especially of bone resorption. In this study, serum bone Gla-protein (BGP), marker of osteoblastic function, and serum carboxyterminal telopeptide of type I collagen (ICTP), index of bone resorption, were evaluated in 6 patients with primary hyperparathyroidism before, 10 days and 3 months after surgery. Mean baseline BGP (25.0±3.4 ng/ml) and ICTP (5.7±0.5 ng/ml) levels were significantly higher than in normal subjects. After parathyroidectomy, serum BGP and ICTP levels promptly decreased (at 10th day, BGP: 14.7±2.5 ng/ml; ICTP: 3.8±0.2 ng/ml), but remained significantly higher than those recorded in controls. Three months after surgery, serum ICTP levels normalized, while BGP levels remained significantly higher than in normals. In conclusion, our data show that serial determinations of serum BGP and of ICTP levels may be useful in monitoring the course of primary hyperparathyroidism.

AB - The accurate biochemical evaluation of bone turnover is often prevented by the lack of specific and reliable markers of bone formation and especially of bone resorption. In this study, serum bone Gla-protein (BGP), marker of osteoblastic function, and serum carboxyterminal telopeptide of type I collagen (ICTP), index of bone resorption, were evaluated in 6 patients with primary hyperparathyroidism before, 10 days and 3 months after surgery. Mean baseline BGP (25.0±3.4 ng/ml) and ICTP (5.7±0.5 ng/ml) levels were significantly higher than in normal subjects. After parathyroidectomy, serum BGP and ICTP levels promptly decreased (at 10th day, BGP: 14.7±2.5 ng/ml; ICTP: 3.8±0.2 ng/ml), but remained significantly higher than those recorded in controls. Three months after surgery, serum ICTP levels normalized, while BGP levels remained significantly higher than in normals. In conclusion, our data show that serial determinations of serum BGP and of ICTP levels may be useful in monitoring the course of primary hyperparathyroidism.

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