Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European prospective investigation into cancer and nutrition

Mazda Jenab, Elio Riboli, Rebecca J. Cleveland, Teresa Norat, Sabina Rinaldi, Alexandra Nieters, Carine Biessy, Ann Tjønneland, Anja Olsen, Kim Overvad, Henning Grønbæk, Françoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Jakob Linseisen, Heiner Boeing, Tobias Pischon, Dimitrios Trichopoulos, Eleni Oikonomou, Antonia Trichopoulou, Salvatore PanicoPaolo Vineis, Franco Berrino, Rosario Tumino, Giovanna Masala, Petra H. Peters, Carla H. Van Gils, H. Bas Bueno-de-Mesquita, Marga C. Ocké, Eiliv Lund, Michelle A. Mendez, María José Tormo, Aurelio Barricarte, Carmen Martínez-García, Miren Dorronsoro, José Ramón Quirós, Göran Hallmans, Richard Palmqvist, Göran Berglund, Jonas Manjer, Timothy Key, Naomi E. Allen, Sheila Bingham, Kay Tee Khaw, Anne Cust, Rudolf Kaaks

Research output: Contribution to journalArticlepeer-review

Abstract

Western style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. Higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of IGF-I and decreasing the bioactivity of some of its binding proteins. The objective of this study was to determine the association of increasing levels of serum C-peptide, a biomarker of pancreatic insulin secretion, and IGF binding proteins (IGFBP) -1 and -2 with colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 Western European countries. A total of 1,078 colorectal cancer cases were matched (age, date of blood donation, fasting status, gender, study center) to an equal number of control subjects. Relative cancer risks were estimated using conditional logistic regression models. Serum C-peptide concentration was positively associated with an increased colorectal cancer risk for the highest versus the lowest quintile (OR = 1.56, 95% CI = 1.16-2.09, ptrend <0.01), which was slightly attenuated after adjustment for BMI and physical activity (OR = 1.37, 95% CI = 1.00-1.88, ptrend = 0.10). When stratified by anatomical site, the cancer risk was stronger in the colon (OR = 1.67, 95% CI = 1.14-2.46, ptrend <0.01) than in the rectum (OR = 1.42, 95% CI = 0.90-2.25, ptrend = 0.35). The cancer risk estimates were not heterogeneous by gender or fasting status. No clear colorectal cancer risk associations were observed for IGFBP-1 or -2. This large prospective study confirms that hyperinsulinemia, as determined by C-peptide levels, is associated with an increased colorectal cancer risk.

Original languageEnglish
Pages (from-to)368-376
Number of pages9
JournalInternational Journal of Cancer
Volume121
Issue number2
DOIs
Publication statusPublished - Jul 15 2007

Keywords

  • C-peptide
  • Colorectal cancer
  • EPIC
  • IGF
  • Insulin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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