Serum Ca-125 concentrations in endometriosis

L. Fedele, L. Arcaini, P. Vercellini, M. Marchini, A. Baglioni, S. Bianchi

Research output: Contribution to journalArticlepeer-review


Serum Ca-125 levels were measured in 154 patients undergoing laparoscopy or laparotomy for infertility and/or pelvic pain. Pelvic endometriosis at various stages was observed in 102 of the patients, and 52 had a visually normal pelvis and served as a control group. We found a significantly higher mean serum Ca-125 concentration in the patients with stages III and IV endometriosis compared with the controls (P <0.001) whereas in the patients with stages I and II disease the mean antigen level was comparable to that of the control group. Considering its low sensitivity (14.7%) the usefulness of serum Ca-125 measurements as an initial diagnostic test for endometriosis is scanty. On the contrary, because of its elevated specificity (100%), this test may be useful in indicating early surgical exploration of the pelvis in cases of infertility and/or dysmenorrhea which are associated with high values of Ca-125.

Original languageEnglish
Pages (from-to)137-139
Number of pages3
JournalActa Europaea Fertilitatis
Issue number3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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