Serum cholinesterase in obsessive-compulsive disorder

Stefano Erzegovesi, Laura Bellodi, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review


Levels of serum cholinesterase (PsChe) were measured in 32 drug-free patients with obsessive-compulsive disorder (OCD) and 32 sex- and age-matched healthy normal volunteers. No significant differences between OCD patients and normal subjects were found in PsChe levels. A significant positive correlation between patients' PsChe levels and the severity of anxiety, as measured by the Hamilton Rating Scale for Anxiety, was found, in agreement with the hypothesis of a relationship between state anxiety and PsChe activity. In contrast to findings in other reports, PsChe levels significantly increased after 10 weeks of antiobsessional pharmacological treatment, underscoring the potential influence of drugs on PsChe activity.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalPsychiatry Research
Issue number3
Publication statusPublished - Oct 16 1995


  • Anxiety
  • Cholinergic system
  • Clomipramine
  • Fluvoxamine

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)


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