Serum concentrations of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and test results from selected residents of seveso, italy

Paolo Mocarelli1, Larry L. Needham, Alessandro Marocchi, Donald G. Patterson, Paolo Brambilla, Pier Mario Gerthoux, Luigi Meazza, Vittorio Carreri

Research output: Contribution to journalArticle

Abstract

2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin levels (TCDD) were measured in serum specimens from Seveso, Italy, residents, who were potentially highly exposed to the 1976 explosion, and in controls. The residents were chosen so as to represent those who did and did not develop chloracne. Levels of TCDD as high as 56, 000 parts per trillion (ppt) were found in these serum specimens that were collected in 1976. These TCDD levels are the highest ever reported, and yet almost all clinical laboratory tests on these individuals were normal; any abnormal test result was only transitory in nature. These findings are unique in linking clinical histories to TCDD levels following an acute exposure.

Original languageEnglish
Pages (from-to)357-366
Number of pages10
JournalJournal of Toxicology and Environmental Health
Volume32
Issue number4
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Toxicology
  • Pollution

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    Mocarelli1, P., Needham, L. L., Marocchi, A., Patterson, D. G., Brambilla, P., Gerthoux, P. M., Meazza, L., & Carreri, V. (1991). Serum concentrations of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and test results from selected residents of seveso, italy. Journal of Toxicology and Environmental Health, 32(4), 357-366. https://doi.org/10.1080/15287399109531490