Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis: Relationship with stage and non-pigmented peritoneal lesions

G. De Placido, C. Alviggi, Palma Di Palma, C. Carravetta, G. Matarese, G. Landino, L. Racioppi

Research output: Contribution to journalArticle

Abstract

Serum concentrations of soluble human leukocyte class I antigens (sHLA-I) and of the intercellular adhesion molecule-1 (sICAM-1) are increased in the early inflammatory stages of several immune-related diseases. These soluble molecules also exert immunomodulatory activity, including regulation of natural killer (NK) cell cytotoxicity. The aim of this study was to verify whether sHLA-I and sICAM-1 serum concentrations are related to the various stages of pelvic endometriosis, which is an immune-related disorder associated with impaired in-vitro NK cell activity. Serum sHLA-I and sICAM-1 concentrations were similar in patients and in healthy donors. However, when evaluated according to disease stage, sHLA-I and sICAM-1 concentrations were higher in patients with endometriosis stage I-II (revised American Fertility Society classification), or with non-pigmented peritoneal lesions. In conclusion, studies on sHLA-I and sICAM-1 may help to clarify the pathogenic mechanisms of endometriosis, and their serum concentrations may serve as additional markers for the early detection of recurrence of the disease during the monitoring of treatment outcome.

Original languageEnglish
Pages (from-to)3206-3210
Number of pages5
JournalHuman Reproduction
Volume13
Issue number11
Publication statusPublished - 1998

Fingerprint

Histocompatibility Antigens Class I
Intercellular Adhesion Molecule-1
Endometriosis
HLA Antigens
Serum
Immune System Diseases
Natural Killer Cells
Fertility
Early Diagnosis
Tissue Donors
Recurrence

Keywords

  • Endometriosis
  • Immune response
  • Non-pigmented lesions
  • sHLA-I
  • sICAM-1

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis : Relationship with stage and non-pigmented peritoneal lesions. / De Placido, G.; Alviggi, C.; Di Palma, Palma; Carravetta, C.; Matarese, G.; Landino, G.; Racioppi, L.

In: Human Reproduction, Vol. 13, No. 11, 1998, p. 3206-3210.

Research output: Contribution to journalArticle

De Placido, G. ; Alviggi, C. ; Di Palma, Palma ; Carravetta, C. ; Matarese, G. ; Landino, G. ; Racioppi, L. / Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis : Relationship with stage and non-pigmented peritoneal lesions. In: Human Reproduction. 1998 ; Vol. 13, No. 11. pp. 3206-3210.
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