Serum copper in Alzheimer

Rosanna Squitti, P. M. Rossini

Research output: Contribution to journalArticle

Abstract

Abnormalities in the homeostasis of brain metals in Alzheimer's disease (AD) can contribute to set up environmental conditions where β-amyloid toxicity and deposition are promoted within areas at risk. Recent studies in man have described possible implications of copper in the AD pathogenesis. In particular, evidence collected in our laboratory in the past six years shows that abnormalities in copper distribution originating from blood stream variations correlate with functional and structural brain deficits in AD. Despite these works supporting a damaging role of copper, new studies hypothesize a protective role. In fact, some recent studies have shown that a decrease of serum copper in man correlates with a worse neuropsychological performance. However, this apparent discrepancy concerns the absolute serum copper levels and can be overcome by considering the fraction of non-ceruloplasmin-copper (NCC).

Original languageEnglish
Pages (from-to)88-93
Number of pages6
JournalResearch and Practice in Alzheimer's Disease
Volume12
Publication statusPublished - 2007

Fingerprint

Copper
Serum
Alzheimer Disease
Brain
Amyloid
Homeostasis
Metals

Keywords

  • β-Amyloid
  • Alzheimer's disease
  • Ceruloplasmin
  • Copper
  • EEG

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Ageing
  • Neuropsychology and Physiological Psychology
  • Biological Psychiatry

Cite this

Serum copper in Alzheimer. / Squitti, Rosanna; Rossini, P. M.

In: Research and Practice in Alzheimer's Disease, Vol. 12, 2007, p. 88-93.

Research output: Contribution to journalArticle

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