Serum Copper is not Altered in Frontotemporal Lobar Degeneration

Rosanna Squitti, Silvia Fostinelli, Mariacristina Siotto, Clarissa Ferrari, Giuliano Binetti, Luisa Benussi, Mauro Rongioletti, Roberta Ghidoni

Research output: Contribution to journalArticle

Abstract

Meta-analyses show copper dyshomeostasis in Alzheimer's disease. However, a study evaluating copper changes in other neurodegenerative forms of dementia has not yet been performed. In this study, we assessed copper, ceruloplasmin, copper not bound to ceruloplasmin, and copper to ceruloplasmin ratio in 85 patients affected by frontotemporal lobar degeneration (FTLD) and 55 healthy controls. Data were analyzed through multivariate ANOVA models taking into account age and sex as covariates and the stratification for FTLD variants, after calculating power analysis to ensure the reliability of the conclusions drawn. The study revealed no difference between the groups.

Original languageEnglish
Pages (from-to)1427-1432
Number of pages6
JournalJournal of Alzheimer's disease : JAD
Volume63
Issue number4
DOIs
Publication statusPublished - 2018

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