Serum Copper is not Altered in Frontotemporal Lobar Degeneration

Rosanna Squitti; Silvia Fostinelli; Mariacristina Siotto; Clarissa Ferrari; Giuliano Binetti; Luisa Benussi; Mauro Rongioletti; Roberta Ghidoni

doi:10.3233/JAD-171074

Serum Copper is not Altered in Frontotemporal Lobar Degeneration

Rosanna Squitti, Silvia Fostinelli, Mariacristina Siotto, Clarissa Ferrari, Giuliano Binetti, Luisa Benussi, Mauro Rongioletti, Roberta Ghidoni

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article

Abstract

Meta-analyses show copper dyshomeostasis in Alzheimer's disease. However, a study evaluating copper changes in other neurodegenerative forms of dementia has not yet been performed. In this study, we assessed copper, ceruloplasmin, copper not bound to ceruloplasmin, and copper to ceruloplasmin ratio in 85 patients affected by frontotemporal lobar degeneration (FTLD) and 55 healthy controls. Data were analyzed through multivariate ANOVA models taking into account age and sex as covariates and the stratification for FTLD variants, after calculating power analysis to ensure the reliability of the conclusions drawn. The study revealed no difference between the groups.

Original language	English
Pages (from-to)	1427-1432
Number of pages	6
Journal	Journal of Alzheimer's disease : JAD
Volume	63
Issue number	4
DOIs	https://doi.org/10.3233/JAD-171074
Publication status	Published - 2018

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Squitti, R., Fostinelli, S., Siotto, M., Ferrari, C., Binetti, G., Benussi, L., Rongioletti, M., & Ghidoni, R. (2018). Serum Copper is not Altered in Frontotemporal Lobar Degeneration. Journal of Alzheimer's disease : JAD, 63(4), 1427-1432. https://doi.org/10.3233/JAD-171074

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abstract = "Meta-analyses show copper dyshomeostasis in Alzheimer's disease. However, a study evaluating copper changes in other neurodegenerative forms of dementia has not yet been performed. In this study, we assessed copper, ceruloplasmin, copper not bound to ceruloplasmin, and copper to ceruloplasmin ratio in 85 patients affected by frontotemporal lobar degeneration (FTLD) and 55 healthy controls. Data were analyzed through multivariate ANOVA models taking into account age and sex as covariates and the stratification for FTLD variants, after calculating power analysis to ensure the reliability of the conclusions drawn. The study revealed no difference between the groups.",

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AU - Squitti, Rosanna

AU - Fostinelli, Silvia

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AU - Binetti, Giuliano

AU - Benussi, Luisa

AU - Rongioletti, Mauro

AU - Ghidoni, Roberta

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AB - Meta-analyses show copper dyshomeostasis in Alzheimer's disease. However, a study evaluating copper changes in other neurodegenerative forms of dementia has not yet been performed. In this study, we assessed copper, ceruloplasmin, copper not bound to ceruloplasmin, and copper to ceruloplasmin ratio in 85 patients affected by frontotemporal lobar degeneration (FTLD) and 55 healthy controls. Data were analyzed through multivariate ANOVA models taking into account age and sex as covariates and the stratification for FTLD variants, after calculating power analysis to ensure the reliability of the conclusions drawn. The study revealed no difference between the groups.

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