Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment

Gianluigi Ardissino, Francesca Tel, Ilaria Possenti, Mariangela Pavesi, Michela Perrone, Giulia Forni, Patrizia Salice, Lorenzo Colombo, Stefano Ghirardello, Bianca Castiglione, Dario Consonni, Laura Baca, Daniela Li Vecchi, Giancarlo la Marca, Fabio Mosca

Research output: Contribution to journalArticle

Abstract

It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. Conclusion: The association between parental AH and high sCr during perinatal dehydration supports the hypothesis that the latter is a promising tool for identifying normal subjects with a reduced nephron mass with potential important implications in prevention and in understanding the individual outcome of renal and extrarenal diseases (including AH).(Table presented.)

Original languageEnglish
Pages (from-to)1383-1388
Number of pages6
JournalEuropean Journal of Pediatrics
Volume177
Issue number9
DOIs
Publication statusPublished - 2018

Fingerprint

Nephrons
Financial Management
Dehydration
Creatinine
Hypertension
Newborn Infant
Serum
Healthy Volunteers
Parturition
Kidney
Mothers
Observation
Blood Pressure
Health

Keywords

  • Arterial hypertension
  • Blood Pressure
  • Nephron endowment
  • Newborn
  • Perinatal serum creatinine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment. / Ardissino, Gianluigi; Tel, Francesca; Possenti, Ilaria; Pavesi, Mariangela; Perrone, Michela; Forni, Giulia; Salice, Patrizia; Colombo, Lorenzo; Ghirardello, Stefano; Castiglione, Bianca; Consonni, Dario; Baca, Laura; Vecchi, Daniela Li; la Marca, Giancarlo; Mosca, Fabio.

In: European Journal of Pediatrics, Vol. 177, No. 9, 2018, p. 1383-1388.

Research output: Contribution to journalArticle

Ardissino, Gianluigi ; Tel, Francesca ; Possenti, Ilaria ; Pavesi, Mariangela ; Perrone, Michela ; Forni, Giulia ; Salice, Patrizia ; Colombo, Lorenzo ; Ghirardello, Stefano ; Castiglione, Bianca ; Consonni, Dario ; Baca, Laura ; Vecchi, Daniela Li ; la Marca, Giancarlo ; Mosca, Fabio. / Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment. In: European Journal of Pediatrics. 2018 ; Vol. 177, No. 9. pp. 1383-1388.
@article{aab74051179e478eadf29b8e74c0c38f,
title = "Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment",
abstract = "It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. Conclusion: The association between parental AH and high sCr during perinatal dehydration supports the hypothesis that the latter is a promising tool for identifying normal subjects with a reduced nephron mass with potential important implications in prevention and in understanding the individual outcome of renal and extrarenal diseases (including AH).(Table presented.)",
keywords = "Arterial hypertension, Blood Pressure, Nephron endowment, Newborn, Perinatal serum creatinine",
author = "Gianluigi Ardissino and Francesca Tel and Ilaria Possenti and Mariangela Pavesi and Michela Perrone and Giulia Forni and Patrizia Salice and Lorenzo Colombo and Stefano Ghirardello and Bianca Castiglione and Dario Consonni and Laura Baca and Vecchi, {Daniela Li} and {la Marca}, Giancarlo and Fabio Mosca",
year = "2018",
doi = "10.1007/s00431-018-3087-0",
language = "English",
volume = "177",
pages = "1383--1388",
journal = "European Journal of Pediatrics",
issn = "0340-6199",
publisher = "Springer Berlin Heidelberg",
number = "9",

}

TY - JOUR

T1 - Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment

AU - Ardissino, Gianluigi

AU - Tel, Francesca

AU - Possenti, Ilaria

AU - Pavesi, Mariangela

AU - Perrone, Michela

AU - Forni, Giulia

AU - Salice, Patrizia

AU - Colombo, Lorenzo

AU - Ghirardello, Stefano

AU - Castiglione, Bianca

AU - Consonni, Dario

AU - Baca, Laura

AU - Vecchi, Daniela Li

AU - la Marca, Giancarlo

AU - Mosca, Fabio

PY - 2018

Y1 - 2018

N2 - It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. Conclusion: The association between parental AH and high sCr during perinatal dehydration supports the hypothesis that the latter is a promising tool for identifying normal subjects with a reduced nephron mass with potential important implications in prevention and in understanding the individual outcome of renal and extrarenal diseases (including AH).(Table presented.)

AB - It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. Conclusion: The association between parental AH and high sCr during perinatal dehydration supports the hypothesis that the latter is a promising tool for identifying normal subjects with a reduced nephron mass with potential important implications in prevention and in understanding the individual outcome of renal and extrarenal diseases (including AH).(Table presented.)

KW - Arterial hypertension

KW - Blood Pressure

KW - Nephron endowment

KW - Newborn

KW - Perinatal serum creatinine

UR - http://www.scopus.com/inward/record.url?scp=85045052042&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045052042&partnerID=8YFLogxK

U2 - 10.1007/s00431-018-3087-0

DO - 10.1007/s00431-018-3087-0

M3 - Article

VL - 177

SP - 1383

EP - 1388

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

SN - 0340-6199

IS - 9

ER -