Serum cystatin C in healthy full-term newborns: Preliminary reference values for a promising endogenous marker of glomerular filtration rate

M. Mussap, M. Plebani, V. Fanos, L. Bertelli, M. Pesce, N. Ruzzante, M. Varagnolo, M. Zaninotto, L. Cataldi

Research output: Contribution to journalArticle

Abstract

Objectives: Human cystatin C is a low-molecular mass protein synthesized at a constant rate by all nucleated cells. The aim of this study was to assess preliminary reference values of serum cystatin C in healthy full-term newborns within the first 3 days of life, and to compare these values with those found in healthy adults. Methods: Twenty healthy full-term newborns as well as 28 healthy adults were studied. In all samples we measured serum cystatin C by a particle-enhanced turbidimetric method. Serum urea, creatinine and sodium, as well as urinary sodium and creatinine were also measured, in order to assess neonatal renal function. Results and discussion: At birth, serum cystatin C levels ranged from 1.55 to 2.98 mg (median value 2.2 mg/l), significantly decreasing 72 h after birth (to a median value of 1.82 mg/l). Analysis of variance followed by the Scheffé multiple comparison test demonstrated a significant difference between neonatal and adult cystatin C values.

Original languageEnglish
Pages (from-to)338-342
Number of pages5
JournalPrenatal and Neonatal Medicine
Volume2
Issue number4
Publication statusPublished - Dec 1997

Keywords

  • Cystatin C
  • Glomerular filtration rate
  • Newborn
  • Particle-enhanced turbidimetry

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Mussap, M., Plebani, M., Fanos, V., Bertelli, L., Pesce, M., Ruzzante, N., Varagnolo, M., Zaninotto, M., & Cataldi, L. (1997). Serum cystatin C in healthy full-term newborns: Preliminary reference values for a promising endogenous marker of glomerular filtration rate. Prenatal and Neonatal Medicine, 2(4), 338-342.