Serum cytokine levels in patients with hepatocellular carcinoma

Francesca Capone, Susan Costantini, Eliana Guerriero, Rosa Calemma, Maria Napolitano, Stefania Scala, Francesco Izzo, Giuseppe Castello

Research output: Contribution to journalArticle

Abstract

The role played by the microenvironment in cancer induction, promotion and progression is crucial. Emerging evidence suggests that cytokines, chemokines and growth factors are major players in carcinogenesis. Therefore, a detailed understanding of factors and mechanisms associated with the processes leading from inflammation to cancer could improve the therapeutic strategies against this disease. We have used hepatocarcinoma as our model in this study. We evaluated the serum levels of 50 different cytokines, chemokines and growth factors in patients affected by HCC with chronic HCV-related hepatitis and liver cirrhosis using multiplex biometric ELISA-based immunoassay. Our data showed that some pro-inflammatory molecules were significantly up-regulated in these patients, and highlighted the complexity of the cytokine network in this disease. This work suggests the need to monitor these proteins in order to define a profile that could characterize patients with HCC or to help identify useful markers. This could lead to better definition of the disease state, and to an increased understanding of the relationships between chronic inflammation and cancer.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalEuropean Cytokine Network
Volume21
Issue number2
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Cancer
  • Chemokines
  • Cytokines
  • Growth factors
  • HCV
  • Hepatocarcinoma

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Biochemistry

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