TY - JOUR
T1 - Serum cytokines and steroidal hormones in polymyalgia rheumatica and elderly-onset rheumatoid arthritis
AU - Cutolo, M.
AU - Montecucco, C. M.
AU - Cavagna, L.
AU - Caporali, R.
AU - Capellino, S.
AU - Montagna, P.
AU - Fazzuoli, L.
AU - Villaggio, B.
AU - Seriolo, B.
AU - Sulli, A.
PY - 2006/11
Y1 - 2006/11
N2 - Background: Polymyalgia rheumatica (PMR) may create some difficulties in the differential diagnosis of elderly-onset rheumatoid arthritis (EORA) and of EORA with PMR-like onset (EORA/PMR). Aim: To investigate possible differences between three groups of patients, with regard to serum levels of inflammatory cytokines and steroidal hormones at baseline and after 1 month of treatment with glucocorticoids (prednisone 7.5-12.5 mg/day). Patients and methods: 14 patients with PMR, 15 with EORA and 14 with EORA/PMR, as well as 15 healthy, matched controls were analysed. Tumour necrosis factor a (TNFα), interleukin (IL)6, IL1 receptor antagonist (IL1Rα), cortisol, dehydroepiandrosterone sulphate (DHEAS) and 17-hydroxy-progesterone (PRG) were evaluated. Results: Serum levels of both TNFα and IL6 were significantly higher in all three groups of patients than in controls (p
AB - Background: Polymyalgia rheumatica (PMR) may create some difficulties in the differential diagnosis of elderly-onset rheumatoid arthritis (EORA) and of EORA with PMR-like onset (EORA/PMR). Aim: To investigate possible differences between three groups of patients, with regard to serum levels of inflammatory cytokines and steroidal hormones at baseline and after 1 month of treatment with glucocorticoids (prednisone 7.5-12.5 mg/day). Patients and methods: 14 patients with PMR, 15 with EORA and 14 with EORA/PMR, as well as 15 healthy, matched controls were analysed. Tumour necrosis factor a (TNFα), interleukin (IL)6, IL1 receptor antagonist (IL1Rα), cortisol, dehydroepiandrosterone sulphate (DHEAS) and 17-hydroxy-progesterone (PRG) were evaluated. Results: Serum levels of both TNFα and IL6 were significantly higher in all three groups of patients than in controls (p
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U2 - 10.1136/ard.2006.051979
DO - 10.1136/ard.2006.051979
M3 - Article
C2 - 16644782
AN - SCOPUS:33750376158
VL - 65
SP - 1438
EP - 1443
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
SN - 0003-4967
IS - 11
ER -