Serum cytokines and steroidal hormones in polymyalgia rheumatica and elderly-onset rheumatoid arthritis

M. Cutolo, C. M. Montecucco, L. Cavagna, R. Caporali, S. Capellino, P. Montagna, L. Fazzuoli, B. Villaggio, B. Seriolo, A. Sulli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Polymyalgia rheumatica (PMR) may create some difficulties in the differential diagnosis of elderly-onset rheumatoid arthritis (EORA) and of EORA with PMR-like onset (EORA/PMR). Aim: To investigate possible differences between three groups of patients, with regard to serum levels of inflammatory cytokines and steroidal hormones at baseline and after 1 month of treatment with glucocorticoids (prednisone 7.5-12.5 mg/day). Patients and methods: 14 patients with PMR, 15 with EORA and 14 with EORA/PMR, as well as 15 healthy, matched controls were analysed. Tumour necrosis factor a (TNFα), interleukin (IL)6, IL1 receptor antagonist (IL1Rα), cortisol, dehydroepiandrosterone sulphate (DHEAS) and 17-hydroxy-progesterone (PRG) were evaluated. Results: Serum levels of both TNFα and IL6 were significantly higher in all three groups of patients than in controls (p

Original languageEnglish
Pages (from-to)1438-1443
Number of pages6
JournalAnnals of the Rheumatic Diseases
Volume65
Issue number11
DOIs
Publication statusPublished - Nov 2006

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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