Abstract
Introduction: Intolerance to various foods, excluding bona fide coeliac disease and lactose intolerance, represents a growing cause of patient visits to allergy clinics. Histamine intolerance is a long-known, multifaceted clinical condition triggered by histamine-rich foods and alcohol and/or by drugs that liberate histamine or block diamine oxidase (DAO), the main enzyme involved in the metabolism of ingested histamine. Histamine limitation diets impose complex, non-standardized restrictions that may severely impact the quality of life of patients. Methods: We retrospectively evaluated 14 patients who visited allergy outpatient facilities in northern Italy with a negative diagnosis for IgE-mediated food hypersensitivity, coeliac disease, conditions related to gastric hypersecretion, and systemic nickel hypersensitivity, and who previously underwent a histamine limitation diet with benefits for their main symptoms. Serum diamine oxidase levels and the clinical response to diamine oxidase supplementation were investigated. Results: We found that 10 out of 14 patients had serum DAO activity
Original language | English |
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Pages (from-to) | 105-111 |
Number of pages | 7 |
Journal | International Journal of Immunopathology and Pharmacology |
Volume | 29 |
Issue number | 1 |
DOIs | |
Publication status | Published - Mar 1 2016 |
Keywords
- diamine oxidase
- food intolerance
- histamine intolerance
- low histamine diet
ASJC Scopus subject areas
- Pharmacology
- Immunology
- Immunology and Allergy