Serum diamine oxidase activity in patients with histamine intolerance

G. Manzotti, D. Breda, M. Di Gioacchino, S. E. Burastero

Research output: Contribution to journalArticlepeer-review


Introduction: Intolerance to various foods, excluding bona fide coeliac disease and lactose intolerance, represents a growing cause of patient visits to allergy clinics. Histamine intolerance is a long-known, multifaceted clinical condition triggered by histamine-rich foods and alcohol and/or by drugs that liberate histamine or block diamine oxidase (DAO), the main enzyme involved in the metabolism of ingested histamine. Histamine limitation diets impose complex, non-standardized restrictions that may severely impact the quality of life of patients. Methods: We retrospectively evaluated 14 patients who visited allergy outpatient facilities in northern Italy with a negative diagnosis for IgE-mediated food hypersensitivity, coeliac disease, conditions related to gastric hypersecretion, and systemic nickel hypersensitivity, and who previously underwent a histamine limitation diet with benefits for their main symptoms. Serum diamine oxidase levels and the clinical response to diamine oxidase supplementation were investigated. Results: We found that 10 out of 14 patients had serum DAO activity

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalInternational Journal of Immunopathology and Pharmacology
Issue number1
Publication statusPublished - Mar 1 2016


  • diamine oxidase
  • food intolerance
  • histamine intolerance
  • low histamine diet

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy


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