Serum dioxin concentrations and bone density and structure in the Seveso women's health study

Brenda Eskenazi, Marcella Warner, Marcella Sirtori, Thomas Fuerst, Stephen A. Rauch, Paolo Brambilla, Paolo Mocarelli, Alessandro Rubinacci

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a widespread environmental contaminant, is a known endocrine disruptor. In animal studies, TCDD exposure impairs bone metabolism and increases fragility. To our knowledge, no epidemiologic studies have examined this association. Objectives: On 10 July 1976, a chemical explosion in Seveso, Italy, resulted in the highest known residential exposure to TCDD. In 1996, we initiated the Seveso Women's Health Study, a retrospective cohort study of the health of the women. In 2008, we followed up the cohort. Here, we evaluated the association between TCDD exposure and bone structure and geometry in adulthood, and considered whether timing of TCDD exposure before achievement of peak bone mass (assumed to occur 2 years after onset of menarche) modified the association. Methods: Individual TCDD concentration was measured in archived serum collected soon after the explosion. In 2008, 350 women who were <20 years old in 1976 underwent a dual-energy X-ray absorptiometry (DXA) bone scan. Bone mineral density was measured at the lumbar spine and hip, and hip geometry was extracted from hip DXA scans using the hip structural analysis method. Results: Among premenopausal women, TCDD serum levels were associated with some indexes indicating better bone structure in women exposed before peak bone mass (n = 219), with stronger associations in those exposed before 5 years of age (n = 46). In contrast, among postmenopausal women, TCDD levels were associated with evidence of better bone structure in women exposed after peak bone mass (n = 48) than in other women (n = 18). Conclusions: Our current results do not support the hypothesis that postnatal TCDD exposure adversely affects adult bone health. Continued follow-up of women who were youngest at exposure is warranted. Future studies should also focus on those exposed in utero.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalEnvironmental Health Perspectives
Volume122
Issue number1
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Dioxins
Women's Health
Bone Density
Bone and Bones
Serum
Hip
Explosions
Photon Absorptiometry
Polychlorinated Dibenzodioxins
Endocrine Disruptors
Menarche
Italy
Epidemiologic Studies
Spine
Cohort Studies
Retrospective Studies
Health

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Serum dioxin concentrations and bone density and structure in the Seveso women's health study. / Eskenazi, Brenda; Warner, Marcella; Sirtori, Marcella; Fuerst, Thomas; Rauch, Stephen A.; Brambilla, Paolo; Mocarelli, Paolo; Rubinacci, Alessandro.

In: Environmental Health Perspectives, Vol. 122, No. 1, 01.2014, p. 51-57.

Research output: Contribution to journalArticle

Eskenazi, B, Warner, M, Sirtori, M, Fuerst, T, Rauch, SA, Brambilla, P, Mocarelli, P & Rubinacci, A 2014, 'Serum dioxin concentrations and bone density and structure in the Seveso women's health study', Environmental Health Perspectives, vol. 122, no. 1, pp. 51-57. https://doi.org/10.1289/ehp.1306788
Eskenazi, Brenda ; Warner, Marcella ; Sirtori, Marcella ; Fuerst, Thomas ; Rauch, Stephen A. ; Brambilla, Paolo ; Mocarelli, Paolo ; Rubinacci, Alessandro. / Serum dioxin concentrations and bone density and structure in the Seveso women's health study. In: Environmental Health Perspectives. 2014 ; Vol. 122, No. 1. pp. 51-57.
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