Endothelins (ETs) are members of a 21 amino acid peptide family represented by ET-1, ET-2 and ET-3, having profound cardiovascular, mitogenic and neuroregulatory actions. These peptides are secreted by different cell types, including human keratinocytes, which in turn express ET-A receptors. Due to the ability of these molecules to stimulate the keratinocyte proliferation, neo-angiogenesis and leukocyte chemotaxis (some the main characteristics of psoriasis), we measured the levels of one of these mediators, namely ET-1, in the sera of a group of patients with active plaque-type psoriasis and in another group of healthy subjects. Our results confirmed that serum ET-1 levels were greater in psoriatic patients than in healthy controls (p <0.05) and also showed a significant correlation between these levels and the psoriasis area and severity index (PASI) scores (R = 0.6, p <0.05). These data, taken all together, suggest a possible involvement of ET-1 in the pathogenesis of psoriasis.
|Number of pages||2|
|Journal||International Journal of Immunopathology and Pharmacology|
|Publication status||Published - 1997|
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