Serum endothelin-1 levels are increased in psoriatic patients and correlate with disease severity

C. Bonifatf, A. Mussi, M. Carducci, A. Pittarello, L. D'Auria, A. Venuti, A. Bagnato, D. Salani, M. Fazio, F. Ameglio

Research output: Contribution to journalArticle

Abstract

Endothelins (ETs) are members of a 21 amino acid peptide family represented by ET-1, ET-2 and ET-3, having profound cardiovascular, mitogenic and neuroregulatory actions. These peptides are secreted by different cell types, including human keratinocytes, which in turn express ET-A receptors. Due to the ability of these molecules to stimulate the keratinocyte proliferation, neo-angiogenesis and leukocyte chemotaxis (some the main characteristics of psoriasis), we measured the levels of one of these mediators, namely ET-1, in the sera of a group of patients with active plaque-type psoriasis and in another group of healthy subjects. Our results confirmed that serum ET-1 levels were greater in psoriatic patients than in healthy controls (p <0.05) and also showed a significant correlation between these levels and the psoriasis area and severity index (PASI) scores (R = 0.6, p <0.05). These data, taken all together, suggest a possible involvement of ET-1 in the pathogenesis of psoriasis.

Original languageEnglish
Pages (from-to)81-82
Number of pages2
JournalInternational Journal of Immunopathology and Pharmacology
Volume10
Issue number1
Publication statusPublished - 1997

Keywords

  • endothelin-1
  • PASI
  • psoriasis

ASJC Scopus subject areas

  • Pharmacology

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