Serum eosinophil cationic protein in patients with atopic dermatitis

R. Paganellia, D. Females-Belasio, D. Carmin, P. Scala, P. Meglio, L. Businco, F. Aiuti

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Abstract

Atopic dermatitis (AD) is a chronic inflammatory disease of the skin, frequently associated with a family history of atopy, raised serum IgE levels and other immunological abnormalities. Both eosinophils and their basic proteins have been detected in the skin lesions of AD patients. We measured the levels of eosinophil cationic protein (ECP) in sera of 24 children with AD and found them to be increased, compared to nonatopic controls, both children and adults. High ECP values were also obtained in 3 patients with the hyper-IgE syndrome. However, no direct relationship between IgE and ECP serum levels could be established. We found no correlation between serum ECP and the number of circulating eosinophils, suggesting that part of ECP was produced by cells infiltrating the tissues. Measurement of ECP might represent a noninvasive tool to assess the activity of AD in relation to eosinophil involvement in this disease.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalInternational Archives of Allergy and Immunology
Volume96
Issue number2
DOIs
Publication statusPublished - 1991

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ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Paganellia, R., Females-Belasio, D., Carmin, D., Scala, P., Meglio, P., Businco, L., & Aiuti, F. (1991). Serum eosinophil cationic protein in patients with atopic dermatitis. International Archives of Allergy and Immunology, 96(2), 175-178. https://doi.org/10.1159/000235490