Serum eosinophil cationic protein (sECP)in subjects with a history of asthma symptoms with or without rhinitis

L. Perfetti, E. Galdi, B. Bramé, L. Speciale, G. Moscato

Research output: Contribution to journalArticle

Abstract

Background: Serum eosinophil cationic protein (sECP) has been proposed as a marker of disease activity in bronchial asthma. The study aimed to evaluate the role of sECP in screening asthmatics in a group of subjects with asthma and rhinitis symptoms, and the relationship between sECP and clinical and functional parameters of asthma. Methods: A total of 185 subjects with asthma symptoms, 149 of them with rhinitis as well, underwent skin tests, spirometry, methacholine (MCH) test, blood sampling for eosinophil percentage (bEOS%) and sECP determination, and nasal secretions smear for eosinophil percentage (nEOS%) determination; PEF values, symptoms, and medication over a period of 4 weeks after sampling for sECP quantitation were recorded on a diary. Results: A total of 99 (53%) subjects received a diagnosis of asthma (asthmatics), and 86 did not (nonasthmatics). In asthmatics, neither sECP nor bEOS% was significantly different from nonasthmatics. In asthmatics, sECP was higher in subjects with increased than in those with normal daily PEF variability (16.4, 6.8-24.4 vs 5.3, 3.9-8.4 μg/I; P

Original languageEnglish
Pages (from-to)962-967
Number of pages6
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume54
Issue number9
DOIs
Publication statusPublished - 1999

Keywords

  • Asthma
  • Bronchial hyperresponsiveness
  • Eosinophil cationic protein (ECP)
  • Eosinophils
  • Peak expiratory flow rate (PER)
  • Spirometry
  • Symptoms

ASJC Scopus subject areas

  • Immunology

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