Serum fatty acids and risk of cutaneous melanoma: A population-based case-control study

Marco Vinceti, Carlotta Malagoli, Laura Iacuzio, Catherine M. Crespi, Sabina Sieri, Vittorio Krogh, Sandra Marmiroli, Giovanni Pellacani, Elisabetta Venturelli

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background. Some observational studies have suggested that excess dietary intake of polyunsaturated fatty acids such as linoleic acid increases cutaneous melanoma risk. We aimed at examining the association between serum fatty acids and melanoma risk by conducting a population-based case-control study in a northern Italy community. Methods. The percentage composition of 12 fatty acids was determined in 51 newly diagnosed melanoma patients and 51 age- and sex-matched population controls by extracting total lipids from serum samples using thin layer and gas chromatography. Conditional logistic regression was used to estimate the relative risk of melanoma associated with tertiles of percentage composition of each fatty acid as well as groupings including saturated, monounsaturated, and polyunsaturated fatty acids. Results. We found a slightly increased melanoma risk for stearic and arachidic acids proportion, with and without adjustment for potential confounders. For an n-3 polyunsaturated fatty acid, docosapentaenoic acid, we found a male-specific direct association with melanoma risk. No other associations emerged for the other saturated, monounsaturated, and polyunsaturated fatty acids, individually or grouped by type. Conclusions. These findings do not suggest a major role of fatty acids, including linoleic acid, on risk of cutaneous melanoma, though their evaluation is limited by the small sample size.

Original languageEnglish
Article number659394
JournalDermatology Research and Practice
Volume2013
DOIs
Publication statusPublished - 2013

Fingerprint

Case-Control Studies
Melanoma
Fatty Acids
Skin
Serum
Population
Unsaturated Fatty Acids
Monounsaturated Fatty Acids
Linoleic Acid
Eicosanoic Acids
Stearic Acids
Population Control
Omega-3 Fatty Acids
Thin Layer Chromatography
Gas Chromatography
Sample Size
Italy
Observational Studies
Logistic Models
Lipids

ASJC Scopus subject areas

  • Dermatology

Cite this

Serum fatty acids and risk of cutaneous melanoma : A population-based case-control study. / Vinceti, Marco; Malagoli, Carlotta; Iacuzio, Laura; Crespi, Catherine M.; Sieri, Sabina; Krogh, Vittorio; Marmiroli, Sandra; Pellacani, Giovanni; Venturelli, Elisabetta.

In: Dermatology Research and Practice, Vol. 2013, 659394, 2013.

Research output: Contribution to journalArticle

Vinceti, M, Malagoli, C, Iacuzio, L, Crespi, CM, Sieri, S, Krogh, V, Marmiroli, S, Pellacani, G & Venturelli, E 2013, 'Serum fatty acids and risk of cutaneous melanoma: A population-based case-control study', Dermatology Research and Practice, vol. 2013, 659394. https://doi.org/10.1155/2013/659394
Vinceti, Marco ; Malagoli, Carlotta ; Iacuzio, Laura ; Crespi, Catherine M. ; Sieri, Sabina ; Krogh, Vittorio ; Marmiroli, Sandra ; Pellacani, Giovanni ; Venturelli, Elisabetta. / Serum fatty acids and risk of cutaneous melanoma : A population-based case-control study. In: Dermatology Research and Practice. 2013 ; Vol. 2013.
@article{b590df2f1992474495dc74bc09945cd4,
title = "Serum fatty acids and risk of cutaneous melanoma: A population-based case-control study",
abstract = "Background. Some observational studies have suggested that excess dietary intake of polyunsaturated fatty acids such as linoleic acid increases cutaneous melanoma risk. We aimed at examining the association between serum fatty acids and melanoma risk by conducting a population-based case-control study in a northern Italy community. Methods. The percentage composition of 12 fatty acids was determined in 51 newly diagnosed melanoma patients and 51 age- and sex-matched population controls by extracting total lipids from serum samples using thin layer and gas chromatography. Conditional logistic regression was used to estimate the relative risk of melanoma associated with tertiles of percentage composition of each fatty acid as well as groupings including saturated, monounsaturated, and polyunsaturated fatty acids. Results. We found a slightly increased melanoma risk for stearic and arachidic acids proportion, with and without adjustment for potential confounders. For an n-3 polyunsaturated fatty acid, docosapentaenoic acid, we found a male-specific direct association with melanoma risk. No other associations emerged for the other saturated, monounsaturated, and polyunsaturated fatty acids, individually or grouped by type. Conclusions. These findings do not suggest a major role of fatty acids, including linoleic acid, on risk of cutaneous melanoma, though their evaluation is limited by the small sample size.",
author = "Marco Vinceti and Carlotta Malagoli and Laura Iacuzio and Crespi, {Catherine M.} and Sabina Sieri and Vittorio Krogh and Sandra Marmiroli and Giovanni Pellacani and Elisabetta Venturelli",
year = "2013",
doi = "10.1155/2013/659394",
language = "English",
volume = "2013",
journal = "Dermatology Research and Practice",
issn = "1687-6105",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Serum fatty acids and risk of cutaneous melanoma

T2 - A population-based case-control study

AU - Vinceti, Marco

AU - Malagoli, Carlotta

AU - Iacuzio, Laura

AU - Crespi, Catherine M.

AU - Sieri, Sabina

AU - Krogh, Vittorio

AU - Marmiroli, Sandra

AU - Pellacani, Giovanni

AU - Venturelli, Elisabetta

PY - 2013

Y1 - 2013

N2 - Background. Some observational studies have suggested that excess dietary intake of polyunsaturated fatty acids such as linoleic acid increases cutaneous melanoma risk. We aimed at examining the association between serum fatty acids and melanoma risk by conducting a population-based case-control study in a northern Italy community. Methods. The percentage composition of 12 fatty acids was determined in 51 newly diagnosed melanoma patients and 51 age- and sex-matched population controls by extracting total lipids from serum samples using thin layer and gas chromatography. Conditional logistic regression was used to estimate the relative risk of melanoma associated with tertiles of percentage composition of each fatty acid as well as groupings including saturated, monounsaturated, and polyunsaturated fatty acids. Results. We found a slightly increased melanoma risk for stearic and arachidic acids proportion, with and without adjustment for potential confounders. For an n-3 polyunsaturated fatty acid, docosapentaenoic acid, we found a male-specific direct association with melanoma risk. No other associations emerged for the other saturated, monounsaturated, and polyunsaturated fatty acids, individually or grouped by type. Conclusions. These findings do not suggest a major role of fatty acids, including linoleic acid, on risk of cutaneous melanoma, though their evaluation is limited by the small sample size.

AB - Background. Some observational studies have suggested that excess dietary intake of polyunsaturated fatty acids such as linoleic acid increases cutaneous melanoma risk. We aimed at examining the association between serum fatty acids and melanoma risk by conducting a population-based case-control study in a northern Italy community. Methods. The percentage composition of 12 fatty acids was determined in 51 newly diagnosed melanoma patients and 51 age- and sex-matched population controls by extracting total lipids from serum samples using thin layer and gas chromatography. Conditional logistic regression was used to estimate the relative risk of melanoma associated with tertiles of percentage composition of each fatty acid as well as groupings including saturated, monounsaturated, and polyunsaturated fatty acids. Results. We found a slightly increased melanoma risk for stearic and arachidic acids proportion, with and without adjustment for potential confounders. For an n-3 polyunsaturated fatty acid, docosapentaenoic acid, we found a male-specific direct association with melanoma risk. No other associations emerged for the other saturated, monounsaturated, and polyunsaturated fatty acids, individually or grouped by type. Conclusions. These findings do not suggest a major role of fatty acids, including linoleic acid, on risk of cutaneous melanoma, though their evaluation is limited by the small sample size.

UR - http://www.scopus.com/inward/record.url?scp=84874594781&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874594781&partnerID=8YFLogxK

U2 - 10.1155/2013/659394

DO - 10.1155/2013/659394

M3 - Article

C2 - 23431289

AN - SCOPUS:84874594781

VL - 2013

JO - Dermatology Research and Practice

JF - Dermatology Research and Practice

SN - 1687-6105

M1 - 659394

ER -