Serum folate concentrations in patients with cortical and subcortical dementias

Carlo Lovati, Daniela Galimberti, Simone Pomati, Elisa Capiluppi, Alberto Dolci, Luisa Scapellato, Silvia Rosa, Enrico Mailland, Massimo Suardelli, Alessandra Vanotti, Francesca Clerici, Donatella Santarato, Mauro Panteghini, Elio Scarpini, Claudio Mariani, Pierluigi Bertora

Research output: Contribution to journalArticlepeer-review


Folic acid is believed to play a role in protection from oxidant stress. Low levels of folic acid had been found in serum from patients with Alzheimer disease (AD). Folate concentration was evaluated in sera from 136 patients with cortical dementia [AD, n = 108; frontotemporal dementia (FTD), n = 28], 57 patients with subcortical dementia [Lewy body disease (LBD), n = 9; corticobasal degeneration (CBD), n = 5; progressive supranuclear palsy (PSP), n = 6; Parkinson disease with dementia (PD-Dem), n = 37], and 76 nondemented, healthy age-matched people. Serum folic acid levels were decreased in patients with AD and FTD as compared with either controls or patients with subcortical dementia (3.60 ± 2.22 and 5.37 ± 2.92 μg/L versus 6.87 ± 3.50 μg/L, respectively; P <0.01). A tendency towards decreased folate concentration was found in LBD and CBD, but not to a significant extent. The highest proportion of folate-deficient patients was found in CBD, FTD and AD (respectively, 60, 48.2 and 46.3% versus 7.9% in controls; P <0.001). Folate deficiency characterizes FTD as well as AD. These differences observed among different clinical dementing syndromes may be related to neocortical damage.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
JournalNeuroscience Letters
Issue number3
Publication statusPublished - Jun 15 2007


  • Alzheimer disease
  • Folic acid
  • Frontotemporal dementia
  • Neurodegenerative diseases

ASJC Scopus subject areas

  • Neuroscience(all)


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