TY - JOUR
T1 - Serum folate concentrations in patients with cortical and subcortical dementias
AU - Lovati, Carlo
AU - Galimberti, Daniela
AU - Pomati, Simone
AU - Capiluppi, Elisa
AU - Dolci, Alberto
AU - Scapellato, Luisa
AU - Rosa, Silvia
AU - Mailland, Enrico
AU - Suardelli, Massimo
AU - Vanotti, Alessandra
AU - Clerici, Francesca
AU - Santarato, Donatella
AU - Panteghini, Mauro
AU - Scarpini, Elio
AU - Mariani, Claudio
AU - Bertora, Pierluigi
PY - 2007/6/15
Y1 - 2007/6/15
N2 - Folic acid is believed to play a role in protection from oxidant stress. Low levels of folic acid had been found in serum from patients with Alzheimer disease (AD). Folate concentration was evaluated in sera from 136 patients with cortical dementia [AD, n = 108; frontotemporal dementia (FTD), n = 28], 57 patients with subcortical dementia [Lewy body disease (LBD), n = 9; corticobasal degeneration (CBD), n = 5; progressive supranuclear palsy (PSP), n = 6; Parkinson disease with dementia (PD-Dem), n = 37], and 76 nondemented, healthy age-matched people. Serum folic acid levels were decreased in patients with AD and FTD as compared with either controls or patients with subcortical dementia (3.60 ± 2.22 and 5.37 ± 2.92 μg/L versus 6.87 ± 3.50 μg/L, respectively; P <0.01). A tendency towards decreased folate concentration was found in LBD and CBD, but not to a significant extent. The highest proportion of folate-deficient patients was found in CBD, FTD and AD (respectively, 60, 48.2 and 46.3% versus 7.9% in controls; P <0.001). Folate deficiency characterizes FTD as well as AD. These differences observed among different clinical dementing syndromes may be related to neocortical damage.
AB - Folic acid is believed to play a role in protection from oxidant stress. Low levels of folic acid had been found in serum from patients with Alzheimer disease (AD). Folate concentration was evaluated in sera from 136 patients with cortical dementia [AD, n = 108; frontotemporal dementia (FTD), n = 28], 57 patients with subcortical dementia [Lewy body disease (LBD), n = 9; corticobasal degeneration (CBD), n = 5; progressive supranuclear palsy (PSP), n = 6; Parkinson disease with dementia (PD-Dem), n = 37], and 76 nondemented, healthy age-matched people. Serum folic acid levels were decreased in patients with AD and FTD as compared with either controls or patients with subcortical dementia (3.60 ± 2.22 and 5.37 ± 2.92 μg/L versus 6.87 ± 3.50 μg/L, respectively; P <0.01). A tendency towards decreased folate concentration was found in LBD and CBD, but not to a significant extent. The highest proportion of folate-deficient patients was found in CBD, FTD and AD (respectively, 60, 48.2 and 46.3% versus 7.9% in controls; P <0.001). Folate deficiency characterizes FTD as well as AD. These differences observed among different clinical dementing syndromes may be related to neocortical damage.
KW - Alzheimer disease
KW - Folic acid
KW - Frontotemporal dementia
KW - Neurodegenerative diseases
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U2 - 10.1016/j.neulet.2007.04.060
DO - 10.1016/j.neulet.2007.04.060
M3 - Article
C2 - 17532571
AN - SCOPUS:34249812356
VL - 420
SP - 213
EP - 216
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -