Serum Follicle-Stimulating Hormone and Risk of Epithelial Ovarian Cancer in Postmenopausal Women

Alan A. Arslan, Anne Zeleniuch-Jacquotte, Eva Lundin, Andrea Micheli, Annekatrin Lukanova, Yelena Afanasyeva, Per Lenner, Vittorio Krogh, Paola Muti, Sabina Rinaldi, Rudolf Kaaks, Franco Berrino, Göran Hallmans, Paolo Toniolo

Research output: Contribution to journalArticle

Abstract

The "gonadotropin hypothesis" postulates that gonadotropin overstimulation of ovarian epithelium results in its increased proliferation and subsequent malignant transformation. To address this hypothesis, we assessed the association between prediagnostic serum levels of follicle-stimulating hormone (FSH) and the risk of epithelial ovarian cancer in postmenopausal women who were part of a case-control study nested within three prospective cohorts in New York City, Umeå, Sweden, and Milan, Italy. Case subjects were 88 women with primary invasive epithelial ovarian cancer diagnosed between 3 months and 13.1 years after the blood donation. Controls were 168 women who were free of cancer and matched the case on cohort, age, and enrollment date. Serum FSH was determined using a quantitative immunoradiometric assay. FSH concentrations were similar in women who subsequently received a diagnosis of epithelial ovarian cancer (median, 44.0 mIU/ml; range, 13.8-101.2) and in controls (median, 43.4 mIU/ml; range, 13.5-109.5; P = 0.17). Compared with women in the lowest third, women in the highest third of serum FSH were not at increased risk of epithelial ovarian cancer after an adjustment for potential confounders (odds ratio, 0.85; 95% confidence interval, 0.36-1.99). These observations provide no evidence for an association between circulating FSH and risk of epithelial ovarian cancer in postmenopausal women and do not appear to support the gonadotropin hypothesis of epithelial ovarian carcinogenesis.

Original languageEnglish
Pages (from-to)1531-1535
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume12
Issue number12
Publication statusPublished - Dec 2003

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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  • Cite this

    Arslan, A. A., Zeleniuch-Jacquotte, A., Lundin, E., Micheli, A., Lukanova, A., Afanasyeva, Y., Lenner, P., Krogh, V., Muti, P., Rinaldi, S., Kaaks, R., Berrino, F., Hallmans, G., & Toniolo, P. (2003). Serum Follicle-Stimulating Hormone and Risk of Epithelial Ovarian Cancer in Postmenopausal Women. Cancer Epidemiology Biomarkers and Prevention, 12(12), 1531-1535.