Serum from patients with acute coronary syndromes displays a proapoptotic effect on human endothelial cells: A possible link to pan-coronary syndromes

Marco Valgimigli, Laura Agnoletti, Salvatore Curello, Laura Comini, Gloria Francolini, Francesca Mastrorilli, Elisa Merli, Roberto Pirani, Gabriele Guardigli, Pier Giovanni Grigolato, Roberto Ferrari

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Endothelial apoptosis of atherosclerotic lesions is a possible determinant for the stable-to-vulnerable plaque transition. Recent data support the notion that plaque activation may be a pan-coronary process, advocating the existence of circulating triggers. Methods and Results - Serum from 40 healthy subjects (group 1) and 73 patients with stable angina (n=32; group 2) or acute coronary syndromes (n=41; group 3) was incubated with human umbilical vein endothelial cells, The percentage of apoptosis by flow cytometry and Fas, Bax, and Bcl-2 protein expression by immunoblotting were evaluated at entry in patients and control subjects and repeated after 12 months in group 3. At baseline, apoptotic nuclei were higher in group 3 (14±6%) than in group 2 (3.3±1.8%) and group 1 (1.35±0.8%) (P

Original languageEnglish
Pages (from-to)264-270
Number of pages7
JournalCirculation
Volume107
Issue number2
DOIs
Publication statusPublished - Jan 21 2003

Keywords

  • Apoptosis
  • Endothelium
  • Inflammation
  • Interleukins
  • Plaque

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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