Serum glucagon concentration and hyperinsulinaemia influence renal haemodynamics and urinary protein loss in normotensive patients with central obesity

S. Bruno Solerte, M. Rondanelli, R. Giacchero, M. Stabile, E. Lovati, L. Cravello, B. Pontiggia, G. Vignati, E. Ferrari, M. Fioravanti

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Insulin-resistance syndrome and hyperinsulinaemia are linked with cardiovascular disease (CVD) in the obese population. In particular, cardiovascular risk is more frequent in central obesity and is associated with microalbuminuria (MA). MA and changes of glomerular permeability to proteins in obesity might be related with renal haemodynamic modifications (that is glomerular hyperfiltration). Since glucagon is physiologically involved in renal haemodynamic regulation, the purpose of this study was to examine whether changes of circulating glucagon levels might haemodynamically induce MA and proteinuria in patients with central obesity. SUBJECTS: Forty normotensive obese out-patients, 22 with central (CO group) and 18 with peripheral (PO group) body fat distribution and 11 healthy subjects. MEASUREMENTS: Serum insulin and glucagon concentrations (fasting and after oral glucose tolerance test (OGTT)) by radio immune assay (RIA); glomerular filtration rate (GFR, isotopic); total clearances and urinary excretion rates of albumin (AER), IgG (IgGER) and α1 microglobulin (computerized immunonephelometry). RESULTS: GFR and insulin concentrations (fasting and during OGTT) were higher in the CO than the PO group. Fasting glucagon concentrations were increased, and not physiologically suppressed during OGTT in patients with CO (fasting, P <0.05; OGTT 60 and 120 min, P <0.001 vs PO group). Moreover, glucagon concentrations were significantly correlated with GFR in the CO group (fasting, r = 0.49, P <0.05; 60 min after OGTT, r = 0.58, P <0.01); whereas no correlations were found in the PO group. Higher AER (P <0.001), IgGER (P <0.001) and α1 microglobulin (P <0.05) urinary concentrations were found in patients with CO than in the PO group. CONCLUSIONS: The increase of serum glucagon concentrations may be associated with the enhancement of GFR in patients with central obesity. Glomerular hyperfiltration might influence the development of MA and of proteinuria by means of a haemodynamic mechanism so contributing to increase the risk of renal microvascular complications and of CVD in central obesity.

Original languageEnglish
Pages (from-to)997-1003
Number of pages7
JournalInternational Journal of Obesity
Volume23
Issue number9
Publication statusPublished - 1999

Fingerprint

protein depletion
hyperinsulinemia
Abdominal Obesity
glucagon
Hyperinsulinism
hemodynamics
Glucagon
Carbon Monoxide
Glucose Tolerance Test
obesity
Hemodynamics
fasting
kidneys
Fasting
Kidney
Serum
Proteins
Proteinuria
cardiovascular diseases
Cardiovascular Diseases

Keywords

  • α1 microglobulin
  • Albuminuria
  • Arterial blood pressure
  • Body fat distribution
  • Cardiovascular disease
  • Glomerular filtration rate
  • Glucagon
  • Insulin
  • NEFA
  • Obesity
  • Proteinuria

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Serum glucagon concentration and hyperinsulinaemia influence renal haemodynamics and urinary protein loss in normotensive patients with central obesity. / Solerte, S. Bruno; Rondanelli, M.; Giacchero, R.; Stabile, M.; Lovati, E.; Cravello, L.; Pontiggia, B.; Vignati, G.; Ferrari, E.; Fioravanti, M.

In: International Journal of Obesity, Vol. 23, No. 9, 1999, p. 997-1003.

Research output: Contribution to journalArticle

Solerte, SB, Rondanelli, M, Giacchero, R, Stabile, M, Lovati, E, Cravello, L, Pontiggia, B, Vignati, G, Ferrari, E & Fioravanti, M 1999, 'Serum glucagon concentration and hyperinsulinaemia influence renal haemodynamics and urinary protein loss in normotensive patients with central obesity', International Journal of Obesity, vol. 23, no. 9, pp. 997-1003.
Solerte, S. Bruno ; Rondanelli, M. ; Giacchero, R. ; Stabile, M. ; Lovati, E. ; Cravello, L. ; Pontiggia, B. ; Vignati, G. ; Ferrari, E. ; Fioravanti, M. / Serum glucagon concentration and hyperinsulinaemia influence renal haemodynamics and urinary protein loss in normotensive patients with central obesity. In: International Journal of Obesity. 1999 ; Vol. 23, No. 9. pp. 997-1003.
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abstract = "OBJECTIVES: Insulin-resistance syndrome and hyperinsulinaemia are linked with cardiovascular disease (CVD) in the obese population. In particular, cardiovascular risk is more frequent in central obesity and is associated with microalbuminuria (MA). MA and changes of glomerular permeability to proteins in obesity might be related with renal haemodynamic modifications (that is glomerular hyperfiltration). Since glucagon is physiologically involved in renal haemodynamic regulation, the purpose of this study was to examine whether changes of circulating glucagon levels might haemodynamically induce MA and proteinuria in patients with central obesity. SUBJECTS: Forty normotensive obese out-patients, 22 with central (CO group) and 18 with peripheral (PO group) body fat distribution and 11 healthy subjects. MEASUREMENTS: Serum insulin and glucagon concentrations (fasting and after oral glucose tolerance test (OGTT)) by radio immune assay (RIA); glomerular filtration rate (GFR, isotopic); total clearances and urinary excretion rates of albumin (AER), IgG (IgGER) and α1 microglobulin (computerized immunonephelometry). RESULTS: GFR and insulin concentrations (fasting and during OGTT) were higher in the CO than the PO group. Fasting glucagon concentrations were increased, and not physiologically suppressed during OGTT in patients with CO (fasting, P <0.05; OGTT 60 and 120 min, P <0.001 vs PO group). Moreover, glucagon concentrations were significantly correlated with GFR in the CO group (fasting, r = 0.49, P <0.05; 60 min after OGTT, r = 0.58, P <0.01); whereas no correlations were found in the PO group. Higher AER (P <0.001), IgGER (P <0.001) and α1 microglobulin (P <0.05) urinary concentrations were found in patients with CO than in the PO group. CONCLUSIONS: The increase of serum glucagon concentrations may be associated with the enhancement of GFR in patients with central obesity. Glomerular hyperfiltration might influence the development of MA and of proteinuria by means of a haemodynamic mechanism so contributing to increase the risk of renal microvascular complications and of CVD in central obesity.",
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T1 - Serum glucagon concentration and hyperinsulinaemia influence renal haemodynamics and urinary protein loss in normotensive patients with central obesity

AU - Solerte, S. Bruno

AU - Rondanelli, M.

AU - Giacchero, R.

AU - Stabile, M.

AU - Lovati, E.

AU - Cravello, L.

AU - Pontiggia, B.

AU - Vignati, G.

AU - Ferrari, E.

AU - Fioravanti, M.

PY - 1999

Y1 - 1999

N2 - OBJECTIVES: Insulin-resistance syndrome and hyperinsulinaemia are linked with cardiovascular disease (CVD) in the obese population. In particular, cardiovascular risk is more frequent in central obesity and is associated with microalbuminuria (MA). MA and changes of glomerular permeability to proteins in obesity might be related with renal haemodynamic modifications (that is glomerular hyperfiltration). Since glucagon is physiologically involved in renal haemodynamic regulation, the purpose of this study was to examine whether changes of circulating glucagon levels might haemodynamically induce MA and proteinuria in patients with central obesity. SUBJECTS: Forty normotensive obese out-patients, 22 with central (CO group) and 18 with peripheral (PO group) body fat distribution and 11 healthy subjects. MEASUREMENTS: Serum insulin and glucagon concentrations (fasting and after oral glucose tolerance test (OGTT)) by radio immune assay (RIA); glomerular filtration rate (GFR, isotopic); total clearances and urinary excretion rates of albumin (AER), IgG (IgGER) and α1 microglobulin (computerized immunonephelometry). RESULTS: GFR and insulin concentrations (fasting and during OGTT) were higher in the CO than the PO group. Fasting glucagon concentrations were increased, and not physiologically suppressed during OGTT in patients with CO (fasting, P <0.05; OGTT 60 and 120 min, P <0.001 vs PO group). Moreover, glucagon concentrations were significantly correlated with GFR in the CO group (fasting, r = 0.49, P <0.05; 60 min after OGTT, r = 0.58, P <0.01); whereas no correlations were found in the PO group. Higher AER (P <0.001), IgGER (P <0.001) and α1 microglobulin (P <0.05) urinary concentrations were found in patients with CO than in the PO group. CONCLUSIONS: The increase of serum glucagon concentrations may be associated with the enhancement of GFR in patients with central obesity. Glomerular hyperfiltration might influence the development of MA and of proteinuria by means of a haemodynamic mechanism so contributing to increase the risk of renal microvascular complications and of CVD in central obesity.

AB - OBJECTIVES: Insulin-resistance syndrome and hyperinsulinaemia are linked with cardiovascular disease (CVD) in the obese population. In particular, cardiovascular risk is more frequent in central obesity and is associated with microalbuminuria (MA). MA and changes of glomerular permeability to proteins in obesity might be related with renal haemodynamic modifications (that is glomerular hyperfiltration). Since glucagon is physiologically involved in renal haemodynamic regulation, the purpose of this study was to examine whether changes of circulating glucagon levels might haemodynamically induce MA and proteinuria in patients with central obesity. SUBJECTS: Forty normotensive obese out-patients, 22 with central (CO group) and 18 with peripheral (PO group) body fat distribution and 11 healthy subjects. MEASUREMENTS: Serum insulin and glucagon concentrations (fasting and after oral glucose tolerance test (OGTT)) by radio immune assay (RIA); glomerular filtration rate (GFR, isotopic); total clearances and urinary excretion rates of albumin (AER), IgG (IgGER) and α1 microglobulin (computerized immunonephelometry). RESULTS: GFR and insulin concentrations (fasting and during OGTT) were higher in the CO than the PO group. Fasting glucagon concentrations were increased, and not physiologically suppressed during OGTT in patients with CO (fasting, P <0.05; OGTT 60 and 120 min, P <0.001 vs PO group). Moreover, glucagon concentrations were significantly correlated with GFR in the CO group (fasting, r = 0.49, P <0.05; 60 min after OGTT, r = 0.58, P <0.01); whereas no correlations were found in the PO group. Higher AER (P <0.001), IgGER (P <0.001) and α1 microglobulin (P <0.05) urinary concentrations were found in patients with CO than in the PO group. CONCLUSIONS: The increase of serum glucagon concentrations may be associated with the enhancement of GFR in patients with central obesity. Glomerular hyperfiltration might influence the development of MA and of proteinuria by means of a haemodynamic mechanism so contributing to increase the risk of renal microvascular complications and of CVD in central obesity.

KW - α1 microglobulin

KW - Albuminuria

KW - Arterial blood pressure

KW - Body fat distribution

KW - Cardiovascular disease

KW - Glomerular filtration rate

KW - Glucagon

KW - Insulin

KW - NEFA

KW - Obesity

KW - Proteinuria

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