Serum gonadotropin and steroid patterns during the normal menstrual cycle

Daniel R. Mishell, Robert M. Nakamura, Pier Giorgio Crosignani, Sergio Stone, Khalil Kharma, Yukihiro Nagata, Ian H. Thorneycroft

Research output: Contribution to journalArticlepeer-review


Follicle-stimulating hormone (FSH), luteinizing hormone (LH), progesterone, and estradiol were measured in aliquots of the same serum samples obtained daily from a group of 10 women throughout a normal cycle. Measurement of each of these hormones was performed by sensitive and specific competitive binding techniques. The patterns and mean levels of each of these hormones in this group of unselected ovulatory cycles is in general agreement with the results obtained by combining the findings of other investigators. In the early follicular phase, there are higher levels of FSH, followed by rising levels of estradiol which reach a peak at mid-cycle. A peak in LH occurs on the same or subsequent day, and it in turn is followed by a rise in progesterone and a secondary rise in progesterone and in estradiol. Both these steroids then fall a few days prior to menstruation.

Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1
Publication statusPublished - Sep 1 1971

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology


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