Serum heme-albumin: An allosteric protein

Paolo Ascenzi, Mauro Fasano

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Heme scavenging by plasma proteins, including serum albumin (SA), provides protection against free-heme oxidative damage, limits access by pathogens to the heme, and contributes to iron homeostasis by recycling the heme iron. In turn, serum heme-albumin (SA-heme) acquires heme-based ligand-binding and (pseudo-)enzymatic properties. Heme binding to SA and SA-heme reactivity are allosterically and competitively modulated by endogenous and exogenous third components, this being relevant in pharmacotherapy management.

Original languageEnglish
Pages (from-to)1118-1122
Number of pages5
JournalIUBMB Life
Volume61
Issue number12
DOIs
Publication statusPublished - 2009

Fingerprint

Heme
Serum Albumin
Albumins
Proteins
Iron
Drug therapy
Scavenging
Recycling
Pathogens
Blood Proteins
Homeostasis
Ligands
Drug Therapy

Keywords

  • Allosteric modulation
  • Heme binding
  • Serum heme-albumin
  • Serum heme-albumin reactivity

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Ascenzi, P., & Fasano, M. (2009). Serum heme-albumin: An allosteric protein. IUBMB Life, 61(12), 1118-1122. https://doi.org/10.1002/iub.263

Serum heme-albumin : An allosteric protein. / Ascenzi, Paolo; Fasano, Mauro.

In: IUBMB Life, Vol. 61, No. 12, 2009, p. 1118-1122.

Research output: Contribution to journalArticle

Ascenzi, P & Fasano, M 2009, 'Serum heme-albumin: An allosteric protein', IUBMB Life, vol. 61, no. 12, pp. 1118-1122. https://doi.org/10.1002/iub.263
Ascenzi, Paolo ; Fasano, Mauro. / Serum heme-albumin : An allosteric protein. In: IUBMB Life. 2009 ; Vol. 61, No. 12. pp. 1118-1122.
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