Serum heme-albumin: An allosteric protein

Paolo Ascenzi, Mauro Fasano

Research output: Contribution to journalArticlepeer-review


Heme scavenging by plasma proteins, including serum albumin (SA), provides protection against free-heme oxidative damage, limits access by pathogens to the heme, and contributes to iron homeostasis by recycling the heme iron. In turn, serum heme-albumin (SA-heme) acquires heme-based ligand-binding and (pseudo-)enzymatic properties. Heme binding to SA and SA-heme reactivity are allosterically and competitively modulated by endogenous and exogenous third components, this being relevant in pharmacotherapy management.

Original languageEnglish
Pages (from-to)1118-1122
Number of pages5
JournalIUBMB Life
Issue number12
Publication statusPublished - 2009


  • Allosteric modulation
  • Heme binding
  • Serum heme-albumin
  • Serum heme-albumin reactivity

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics


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