The levels of serum HLA class I antigens were determined at weekly intervals up to 5 weeks in 46 patients who had undergone allogeneic BMT. In patients with GVHD grade I or with GVHD grade I and fever of unknown origin (FUO), serum HLA class I antigen levels did not change during the observation period. In patients with GVHD grade II-IV serum HLA class I antigen level significantly increased in the week before the onset of GVHD, was maximal at the onset of GVHD and then persisted unchanged in the following 2 weeks. In patients with GVHD grade I or GVHD grade II-IV and infections whose onset coincided with that of acute GVHD a significant increase of serum HLA class I antigen level was found 2 weeks after the onset of the infectious episode. An increase of serum HLA class I antigen level was also found before the onset of repetitive GVHD grade II-IV episodes as well as during and after infectious episodes whose onset occurred after the onset of acute GVHD. The mean ± s.d. concentrations of serum HLA class I antigens during GVHD grade II-IV episodes (9.4 ± 3.4 μg/ml) and 2 weeks after the onset of infectious episodes (7.1 ± 1.6 μg/ml) are significantly (P <0.01 and P <0.05, respectively) higher than that found 2 weeks before the onset of GVHD (3.0 ± 0.5 μg/ml). The results of the present investigation suggest that measurement of serum HLA class I antigen level may be a possible marker to detect an acute GVHD following BMT.
|Number of pages||6|
|Journal||Bone Marrow Transplantation|
|Publication status||Published - May 1996|
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