Serum HLA class I antigen levels in allogeneic bone marrow transplantation: A possible marker of acute GVHD

F. Puppo, S. Brenci, M. Ghio, D. Bignardi, P. Contini, A. Bacigalupo, M. T. Van Lint, M. Scudeletti, S. Ferrone, F. Indiveri

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Abstract

The levels of serum HLA class I antigens were determined at weekly intervals up to 5 weeks in 46 patients who had undergone allogeneic BMT. In patients with GVHD grade I or with GVHD grade I and fever of unknown origin (FUO), serum HLA class I antigen levels did not change during the observation period. In patients with GVHD grade II-IV serum HLA class I antigen level significantly increased in the week before the onset of GVHD, was maximal at the onset of GVHD and then persisted unchanged in the following 2 weeks. In patients with GVHD grade I or GVHD grade II-IV and infections whose onset coincided with that of acute GVHD a significant increase of serum HLA class I antigen level was found 2 weeks after the onset of the infectious episode. An increase of serum HLA class I antigen level was also found before the onset of repetitive GVHD grade II-IV episodes as well as during and after infectious episodes whose onset occurred after the onset of acute GVHD. The mean ± s.d. concentrations of serum HLA class I antigens during GVHD grade II-IV episodes (9.4 ± 3.4 μg/ml) and 2 weeks after the onset of infectious episodes (7.1 ± 1.6 μg/ml) are significantly (P <0.01 and P <0.05, respectively) higher than that found 2 weeks before the onset of GVHD (3.0 ± 0.5 μg/ml). The results of the present investigation suggest that measurement of serum HLA class I antigen level may be a possible marker to detect an acute GVHD following BMT.

Original languageEnglish
Pages (from-to)753-758
Number of pages6
JournalBone Marrow Transplantation
Volume17
Issue number5
Publication statusPublished - May 1996

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Keywords

  • BMT
  • GVHD
  • HLA
  • MHC

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Puppo, F., Brenci, S., Ghio, M., Bignardi, D., Contini, P., Bacigalupo, A., Van Lint, M. T., Scudeletti, M., Ferrone, S., & Indiveri, F. (1996). Serum HLA class I antigen levels in allogeneic bone marrow transplantation: A possible marker of acute GVHD. Bone Marrow Transplantation, 17(5), 753-758.