Serum IL-1β levels in health and disease: A population-based study. 'The InCHIANTI study'

Angelo Di Iorio, Luigi Ferrucci, Eleonora Sparvieri, Antonio Cherubini, Stefano Volpato, Annamaria Corsi, Massimo Bonafè, Claudio Franceschi, Giuseppe Abate, Roberto Paganelli

Research output: Contribution to journalArticle

Abstract

Interleukin-1 plays a role in normal homeostasis and in the inflammatory response which is deemed to be responsible for the development of major chronic diseases that are highly prevalent in the elderly. Aim of this study is to evaluate the factors influencing the serum levels of Interleukin-1 β, in a large and representative population. Data were from the InCHIANTI project, a study of factors contributing to the decline of mobility in late life, which sampled people living in two sites in the surroundings of Florence. Blood samples were obtained from 1292 participants and frozen aliquots were stored at -80 °C. The serum levels of several cytokines were measured by enzyme linked immunosorbent assay using an ultrasensitive commercial kit. Interleukin-1 β serum levels were associated with congestive heart failure (p>0.001) and angina (p=0.02), with Ca2+ serum levels (p=0.02), and with a history of dyslipidemia (p=0.05). We found no association between serum IL-1β level and age, sex, consumption of cardioactive drugs and serum levels of IL-1Ra, IL-6, sIL-6R, IL-10 and TNF-α. Our data could lend support to the hypothesis that IL-1β is mainly involved in the functional alterations of cardiomyocytes under conditions marked by mononuclear cell infiltration and by downregulation of calcium.

Original languageEnglish
Pages (from-to)198-205
Number of pages8
JournalCytokine
Volume22
Issue number6
DOIs
Publication statusPublished - Jun 21 2003

Keywords

  • Aging
  • Drugs
  • Epidemiology
  • Heart failure
  • Interleukins

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

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    Di Iorio, A., Ferrucci, L., Sparvieri, E., Cherubini, A., Volpato, S., Corsi, A., Bonafè, M., Franceschi, C., Abate, G., & Paganelli, R. (2003). Serum IL-1β levels in health and disease: A population-based study. 'The InCHIANTI study'. Cytokine, 22(6), 198-205. https://doi.org/10.1016/S1043-4666(03)00152-2