Serum IL-23 strongly and inversely correlates with FEV1 in asthmatic children

Giorgio Ciprandi, Caterina Cuppari, Anna Maria Salpietro, Maria Angela Tosca, Luciana Rigoli, Luisa Grasso, Mario La Rosa, Gian Luigi Marseglia, Michele Miraglia Del Giudice, Carmelo Salpietro

Research output: Contribution to journalArticle

Abstract

Background: Recently, Th17 cells have been found to participate in the pathogenesis of allergic asthma. IL-23 is a cytokine that may be implicated in modulating Th17 response. This study aimed at evaluating IL-23 and relating it to lung function in asthmatic children. Methods: Seventy-eight asthmatic children and 40 healthy children were evaluated. Spirometry and serum IL-23 measurement (ELISA kit) were performed in all asthmatic children. Results: IL-23 levels were higher in asthmatic than in healthy children (p <0.001). There was a strong inverse relationship between FEV1 and IL-23 (r = -0.787). Conclusions: This preliminary study suggests that serum IL-23 could be a suitable marker of bronchial function impairment in allergic asthmatic children.

Original languageEnglish
Pages (from-to)183-186
Number of pages4
JournalInternational Archives of Allergy and Immunology
Volume159
Issue number2
DOIs
Publication statusPublished - Sep 2012

Keywords

  • Asthma
  • Children
  • IL-23
  • Lung function

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Ciprandi, G., Cuppari, C., Salpietro, A. M., Tosca, M. A., Rigoli, L., Grasso, L., La Rosa, M., Marseglia, G. L., Del Giudice, M. M., & Salpietro, C. (2012). Serum IL-23 strongly and inversely correlates with FEV1 in asthmatic children. International Archives of Allergy and Immunology, 159(2), 183-186. https://doi.org/10.1159/000336418