Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis

V. Barak, C. Selmi, M. Schlesinger, M. Blank, N. Agmon-Levin, I. Kalickman, M. E. Gershwin, Y. Shoenfeld

Research output: Contribution to journalArticlepeer-review

Abstract

Primary biliary cirrhosis (PBC) is a chronic cholestatic autoimmune liver disease characterized by selective destruction of the intrahepatic bile ducts and highly specific serum anti-mitochondrial autoantibodies (AMA). Several studies have attempted to determine the cytokine pattern characterizing PBC, yet no definitive data have been gathered. The present study was designed to evaluate pro-inflammatory cytokines (IL-1β, IL-6, TNFα), soluble IL-2 receptor (sIL-2R, e.g. soluble CD25), and complement components (C1q, C3, factor B, properdin) levels in sera from 84 patients with PBC and 41 controls. PBC was characterized by significantly higher levels of all pro-inflammatory cytokines when compared to controls; these included IL-1β (433.3 ± 13.2 vs. 316.6 ± 14.7 pg/ml, P 

Original languageEnglish
Pages (from-to)178-182
Number of pages5
JournalJournal of Autoimmunity
Volume33
Issue number3-4
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Autoimmune cholangitis
  • Cytokines
  • PBC
  • Serum markers
  • T regulatory cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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