Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis

V. Barak; C. Selmi; M. Schlesinger; M. Blank; N. Agmon-Levin; I. Kalickman; M. E. Gershwin; Y. Shoenfeld

doi:10.1016/j.jaut.2009.09.010

Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis

V. Barak, C. Selmi, M. Schlesinger, M. Blank, N. Agmon-Levin, I. Kalickman, M. E. Gershwin, Y. Shoenfeld

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Primary biliary cirrhosis (PBC) is a chronic cholestatic autoimmune liver disease characterized by selective destruction of the intrahepatic bile ducts and highly specific serum anti-mitochondrial autoantibodies (AMA). Several studies have attempted to determine the cytokine pattern characterizing PBC, yet no definitive data have been gathered. The present study was designed to evaluate pro-inflammatory cytokines (IL-1β, IL-6, TNFα), soluble IL-2 receptor (sIL-2R, e.g. soluble CD25), and complement components (C1q, C3, factor B, properdin) levels in sera from 84 patients with PBC and 41 controls. PBC was characterized by significantly higher levels of all pro-inflammatory cytokines when compared to controls; these included IL-1β (433.3 ± 13.2 vs. 316.6 ± 14.7 pg/ml, P

Original language	English
Pages (from-to)	178-182
Number of pages	5
Journal	Journal of Autoimmunity
Volume	33
Issue number	3-4
DOIs	https://doi.org/10.1016/j.jaut.2009.09.010
Publication status	Published - Nov 2009

Keywords

Autoimmune cholangitis
Cytokines
PBC
Serum markers
T regulatory cells

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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title = "Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis",

abstract = "Primary biliary cirrhosis (PBC) is a chronic cholestatic autoimmune liver disease characterized by selective destruction of the intrahepatic bile ducts and highly specific serum anti-mitochondrial autoantibodies (AMA). Several studies have attempted to determine the cytokine pattern characterizing PBC, yet no definitive data have been gathered. The present study was designed to evaluate pro-inflammatory cytokines (IL-1β, IL-6, TNFα), soluble IL-2 receptor (sIL-2R, e.g. soluble CD25), and complement components (C1q, C3, factor B, properdin) levels in sera from 84 patients with PBC and 41 controls. PBC was characterized by significantly higher levels of all pro-inflammatory cytokines when compared to controls; these included IL-1β (433.3 ± 13.2 vs. 316.6 ± 14.7 pg/ml, P ",

keywords = "Autoimmune cholangitis, Cytokines, PBC, Serum markers, T regulatory cells",

author = "V. Barak and C. Selmi and M. Schlesinger and M. Blank and N. Agmon-Levin and I. Kalickman and Gershwin, {M. E.} and Y. Shoenfeld",

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AU - Barak, V.

AU - Selmi, C.

AU - Schlesinger, M.

AU - Blank, M.

AU - Agmon-Levin, N.

AU - Kalickman, I.

AU - Gershwin, M. E.

AU - Shoenfeld, Y.

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KW - Cytokines

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KW - Serum markers

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