Serum insulin-like growth factor-I and platelet-derived growth factor as biomarkers of breast cancer prognosis

Patrizia Pasanisi, Elisabetta Venturelli, Daniele Morelli, Luigi Fontana, Giorgio Secreto, Franco Berrino

Research output: Contribution to journalArticle

Abstract

Epidemiologic studies have shown that growth factors and inflammatory mechanisms may affect breast cancer risk and prognosis. The present analysis on 110 postmenopausal breast cancer patients tested if serum insulin-like growthfactor I (IGF-I), platelet-derived growth factor (PDGF), fructosamine, and C-reactive protein, a serum marker of inflammation, are associated with breast cancer relapse. The risk of adverse events after 5.5 years of follow-up was examined by Cox proportional hazards modeling, controlling for hormone receptor status, stage at diagnosis, and for body weight and serum testosterone level, which were known to significantly affect prognosis. PDGF and, to a lesser extent, IGF-I were positively but not significantly associated withth e risk of breast cancer recurrence. By combining PDGF and IGF-I, however, the adjusted hazard ratio of recurrence among the women with both PDGF and IGF-I levels > their median values (respectively, 9.3 and 174.4 ng/mL) was 6.4 (95% confidence interval, 1.5-26.7) compared with the women with PDGF and IGF-I levels ≤ their median values. Fructosamine and C-reactive protein were not associated with recurrences. The results suggest that PDGF may be an important prognostic factor for breast cancer and that IGF-I may increase the risk of recurrence in the presence of high PDGF levels.

Original languageEnglish
Pages (from-to)1719-1722
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Volume17
Issue number7
DOIs
Publication statusPublished - Jul 2008

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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