Serum insulin-like growth factor-I (IGF-I) reference ranges for chemiluminescence assay in childhood and adolescence. Data from a population of in- and out-patients

G. Bedogni, G. Giannone, M. Maghnie, C. Giacomozzi, N. Di Iorgi, S. Pedicelli, E. Peschiaroli, G. Melioli, M. Muraca, M. Cappa, S. Cianfarani

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Insulin-like growth factor I (IGF-I) measurement is widely used for the diagnosis of disorders of GH secretion and sensitivity, and for monitoring of both GH and IGF-I replacement therapies. However, the lack of appropriate reference values obtained from large and representative samples undermines its practical utility. Objective: To establish IGF-I reference values for a commonly used enzyme-labeled chemiluminescent immunometric assay in a large population of children aged 0 to 18. years. Design: Cross-sectional analysis of serum IGF-I levels from samples collected in the two major Italian Children's Hospitals. Subjects and methods: IGF-I was measured using a solid-phase, enzyme-labeled chemiluminescent immunometric assay in 24403 children (50.6% girls) aged 0 to 18. years. Quantile regression coupled to multivariable fractional polynomials was used to produce age- and sex-specific reference values. Main outcome measure: Age- and sex-specific IGF-I reference values. Results and conclusion: Reference values for immunometric assay of IGF-I were produced in a large sample of children and adolescents. Prediction equations were provided to automatize their calculations.

Original languageEnglish
Pages (from-to)134-138
Number of pages5
JournalGrowth Hormone and IGF Research
Volume22
Issue number3-4
DOIs
Publication statusPublished - Jun 2012

Keywords

  • GH deficiency
  • Hypopituitarism
  • Insulin-like growth factor-I
  • Reference ranges

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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