Background: Insulin-like growth factor I (IGF-I) measurement is widely used for the diagnosis of disorders of GH secretion and sensitivity, and for monitoring of both GH and IGF-I replacement therapies. However, the lack of appropriate reference values obtained from large and representative samples undermines its practical utility. Objective: To establish IGF-I reference values for a commonly used enzyme-labeled chemiluminescent immunometric assay in a large population of children aged 0 to 18. years. Design: Cross-sectional analysis of serum IGF-I levels from samples collected in the two major Italian Children's Hospitals. Subjects and methods: IGF-I was measured using a solid-phase, enzyme-labeled chemiluminescent immunometric assay in 24403 children (50.6% girls) aged 0 to 18. years. Quantile regression coupled to multivariable fractional polynomials was used to produce age- and sex-specific reference values. Main outcome measure: Age- and sex-specific IGF-I reference values. Results and conclusion: Reference values for immunometric assay of IGF-I were produced in a large sample of children and adolescents. Prediction equations were provided to automatize their calculations.
- GH deficiency
- Insulin-like growth factor-I
- Reference ranges
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism