Serum interleukin-17 levels are related to clinical severity in allergic rhinitis

G. Ciprandi, M. De Amici, G. Murdaca, D. Fenoglio, F. Ricciardolo, G. Marseglia, M. Tosca

Research output: Contribution to journalArticle

Abstract

Background: T helper (Th)-17 cells are a subset of T helper lymphocytes that exert regulatory activities. Recently, it has been reported that serum interleukin (IL)-17 levels are high in the most severe cases of birch allergy studied outside the pollen season. Objective: The aim of this study was to investigate a possible relationship between serum IL-17 levels and clinical parameters in patients with allergic rhinitis studied during the pollen season. Methods: In all, 56 patients with persistent pollen-induced allergic rhinitis were evaluated during the pollen season. Serum IL-17 levels were evaluated by enzyme-linked immunosorbent assay. Symptoms were assessed by visual analogue scale, drug use was monitored and peripheral eosinophils were counted. Results: Serum IL-17 levels were significantly related to clinical symptoms, drug use and peripheral eosinophil counts (P = 0.0001 for all). Conclusion: This study provides evidence that serum IL-17 level assessment might be considered to classify allergy severity.

Original languageEnglish
Pages (from-to)1375-1378
Number of pages4
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume64
Issue number9
DOIs
Publication statusPublished - Sep 2009

Fingerprint

Interleukin-17
Pollen
Serum
Eosinophils
Hypersensitivity
Th17 Cells
Betula
Helper-Inducer T-Lymphocytes
Visual Analog Scale
Pharmaceutical Preparations
Enzyme-Linked Immunosorbent Assay
Allergic Rhinitis

Keywords

  • Allergen exposure
  • Allergic rhinitis
  • Allergy severity
  • Interleukin-17
  • Pollen season

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Serum interleukin-17 levels are related to clinical severity in allergic rhinitis. / Ciprandi, G.; De Amici, M.; Murdaca, G.; Fenoglio, D.; Ricciardolo, F.; Marseglia, G.; Tosca, M.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 64, No. 9, 09.2009, p. 1375-1378.

Research output: Contribution to journalArticle

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AU - Ciprandi, G.

AU - De Amici, M.

AU - Murdaca, G.

AU - Fenoglio, D.

AU - Ricciardolo, F.

AU - Marseglia, G.

AU - Tosca, M.

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