Serum interleukin-6 levels and joint involvement in polyarticular and pauciarticular juvenile chronic arthritis

F. De Benedetti, P. Robbioni, M. Massa, S. Viola, S. Albani, A. Martini

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

We measured serum and synovial fluid interleukin 6 (IL-6) levels in patients with polyarticular-onset and pauciarticular-onset juvenile chronic arthritis (JCA), using the hybridoma cell line B9. During active disease, but not during remission, serum IL-6 levels were significantly elevated in patients with polyarticular (p <0.0001 vs controls) and in patients with pauciarticular JCA (p <0.01 vs controls). In patients with active polyarticular disease (polyarticular and extended pauciarticular) serum IL-6 levels correlated with the extent and severity of joint involvement (p <0.05), with erythrocyte sedimentation rate values (p <0.005) and with C reactive protein concentrations (p <0.05). In patients with persistent pauciarticular JCA, serum IL-6 levels correlated with the joint swelling score (p <0.05). Synovial fluid IL-6 levels, measured in 5 patients with pauciarticular JCA, were markedly elevated (range 600-24,000 HGF U/ml). In conclusion, our data suggest that IL-6 is an important pathogenic mediator in polyarticular and pauciarticular JCA.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalClinical and Experimental Rheumatology
Volume10
Issue number5
Publication statusPublished - 1992

Fingerprint

Interleukin-6
Joints
Serum
Synovial Fluid
Blood Sedimentation
Hybridomas
C-Reactive Protein
Juvenile pauciarticular chronic arthritis
Cell Line

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Serum interleukin-6 levels and joint involvement in polyarticular and pauciarticular juvenile chronic arthritis. / De Benedetti, F.; Robbioni, P.; Massa, M.; Viola, S.; Albani, S.; Martini, A.

In: Clinical and Experimental Rheumatology, Vol. 10, No. 5, 1992, p. 493-498.

Research output: Contribution to journalArticle

@article{3d36fed597e84582ad1bc200cd5c39a4,
title = "Serum interleukin-6 levels and joint involvement in polyarticular and pauciarticular juvenile chronic arthritis",
abstract = "We measured serum and synovial fluid interleukin 6 (IL-6) levels in patients with polyarticular-onset and pauciarticular-onset juvenile chronic arthritis (JCA), using the hybridoma cell line B9. During active disease, but not during remission, serum IL-6 levels were significantly elevated in patients with polyarticular (p <0.0001 vs controls) and in patients with pauciarticular JCA (p <0.01 vs controls). In patients with active polyarticular disease (polyarticular and extended pauciarticular) serum IL-6 levels correlated with the extent and severity of joint involvement (p <0.05), with erythrocyte sedimentation rate values (p <0.005) and with C reactive protein concentrations (p <0.05). In patients with persistent pauciarticular JCA, serum IL-6 levels correlated with the joint swelling score (p <0.05). Synovial fluid IL-6 levels, measured in 5 patients with pauciarticular JCA, were markedly elevated (range 600-24,000 HGF U/ml). In conclusion, our data suggest that IL-6 is an important pathogenic mediator in polyarticular and pauciarticular JCA.",
author = "{De Benedetti}, F. and P. Robbioni and M. Massa and S. Viola and S. Albani and A. Martini",
year = "1992",
language = "English",
volume = "10",
pages = "493--498",
journal = "Clinical and Experimental Rheumatology",
issn = "0392-856X",
publisher = "Clinical and Experimental Rheumatology S.A.S.",
number = "5",

}

TY - JOUR

T1 - Serum interleukin-6 levels and joint involvement in polyarticular and pauciarticular juvenile chronic arthritis

AU - De Benedetti, F.

AU - Robbioni, P.

AU - Massa, M.

AU - Viola, S.

AU - Albani, S.

AU - Martini, A.

PY - 1992

Y1 - 1992

N2 - We measured serum and synovial fluid interleukin 6 (IL-6) levels in patients with polyarticular-onset and pauciarticular-onset juvenile chronic arthritis (JCA), using the hybridoma cell line B9. During active disease, but not during remission, serum IL-6 levels were significantly elevated in patients with polyarticular (p <0.0001 vs controls) and in patients with pauciarticular JCA (p <0.01 vs controls). In patients with active polyarticular disease (polyarticular and extended pauciarticular) serum IL-6 levels correlated with the extent and severity of joint involvement (p <0.05), with erythrocyte sedimentation rate values (p <0.005) and with C reactive protein concentrations (p <0.05). In patients with persistent pauciarticular JCA, serum IL-6 levels correlated with the joint swelling score (p <0.05). Synovial fluid IL-6 levels, measured in 5 patients with pauciarticular JCA, were markedly elevated (range 600-24,000 HGF U/ml). In conclusion, our data suggest that IL-6 is an important pathogenic mediator in polyarticular and pauciarticular JCA.

AB - We measured serum and synovial fluid interleukin 6 (IL-6) levels in patients with polyarticular-onset and pauciarticular-onset juvenile chronic arthritis (JCA), using the hybridoma cell line B9. During active disease, but not during remission, serum IL-6 levels were significantly elevated in patients with polyarticular (p <0.0001 vs controls) and in patients with pauciarticular JCA (p <0.01 vs controls). In patients with active polyarticular disease (polyarticular and extended pauciarticular) serum IL-6 levels correlated with the extent and severity of joint involvement (p <0.05), with erythrocyte sedimentation rate values (p <0.005) and with C reactive protein concentrations (p <0.05). In patients with persistent pauciarticular JCA, serum IL-6 levels correlated with the joint swelling score (p <0.05). Synovial fluid IL-6 levels, measured in 5 patients with pauciarticular JCA, were markedly elevated (range 600-24,000 HGF U/ml). In conclusion, our data suggest that IL-6 is an important pathogenic mediator in polyarticular and pauciarticular JCA.

UR - http://www.scopus.com/inward/record.url?scp=0026700776&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026700776&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 493

EP - 498

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

SN - 0392-856X

IS - 5

ER -