Abstract
We measured serum and synovial fluid interleukin 6 (IL-6) levels in patients with polyarticular-onset and pauciarticular-onset juvenile chronic arthritis (JCA), using the hybridoma cell line B9. During active disease, but not during remission, serum IL-6 levels were significantly elevated in patients with polyarticular (p <0.0001 vs controls) and in patients with pauciarticular JCA (p <0.01 vs controls). In patients with active polyarticular disease (polyarticular and extended pauciarticular) serum IL-6 levels correlated with the extent and severity of joint involvement (p <0.05), with erythrocyte sedimentation rate values (p <0.005) and with C reactive protein concentrations (p <0.05). In patients with persistent pauciarticular JCA, serum IL-6 levels correlated with the joint swelling score (p <0.05). Synovial fluid IL-6 levels, measured in 5 patients with pauciarticular JCA, were markedly elevated (range 600-24,000 HGF U/ml). In conclusion, our data suggest that IL-6 is an important pathogenic mediator in polyarticular and pauciarticular JCA.
| Original language | English |
|---|---|
| Pages (from-to) | 493-498 |
| Number of pages | 6 |
| Journal | Clinical and Experimental Rheumatology |
| Volume | 10 |
| Issue number | 5 |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Immunology
- Rheumatology
Cite this
Serum interleukin-6 levels and joint involvement in polyarticular and pauciarticular juvenile chronic arthritis. / De Benedetti, F.; Robbioni, P.; Massa, M.; Viola, S.; Albani, S.; Martini, A.
In: Clinical and Experimental Rheumatology, Vol. 10, No. 5, 1992, p. 493-498.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum interleukin-6 levels and joint involvement in polyarticular and pauciarticular juvenile chronic arthritis
AU - De Benedetti, F.
AU - Robbioni, P.
AU - Massa, M.
AU - Viola, S.
AU - Albani, S.
AU - Martini, A.
PY - 1992
Y1 - 1992
N2 - We measured serum and synovial fluid interleukin 6 (IL-6) levels in patients with polyarticular-onset and pauciarticular-onset juvenile chronic arthritis (JCA), using the hybridoma cell line B9. During active disease, but not during remission, serum IL-6 levels were significantly elevated in patients with polyarticular (p <0.0001 vs controls) and in patients with pauciarticular JCA (p <0.01 vs controls). In patients with active polyarticular disease (polyarticular and extended pauciarticular) serum IL-6 levels correlated with the extent and severity of joint involvement (p <0.05), with erythrocyte sedimentation rate values (p <0.005) and with C reactive protein concentrations (p <0.05). In patients with persistent pauciarticular JCA, serum IL-6 levels correlated with the joint swelling score (p <0.05). Synovial fluid IL-6 levels, measured in 5 patients with pauciarticular JCA, were markedly elevated (range 600-24,000 HGF U/ml). In conclusion, our data suggest that IL-6 is an important pathogenic mediator in polyarticular and pauciarticular JCA.
AB - We measured serum and synovial fluid interleukin 6 (IL-6) levels in patients with polyarticular-onset and pauciarticular-onset juvenile chronic arthritis (JCA), using the hybridoma cell line B9. During active disease, but not during remission, serum IL-6 levels were significantly elevated in patients with polyarticular (p <0.0001 vs controls) and in patients with pauciarticular JCA (p <0.01 vs controls). In patients with active polyarticular disease (polyarticular and extended pauciarticular) serum IL-6 levels correlated with the extent and severity of joint involvement (p <0.05), with erythrocyte sedimentation rate values (p <0.005) and with C reactive protein concentrations (p <0.05). In patients with persistent pauciarticular JCA, serum IL-6 levels correlated with the joint swelling score (p <0.05). Synovial fluid IL-6 levels, measured in 5 patients with pauciarticular JCA, were markedly elevated (range 600-24,000 HGF U/ml). In conclusion, our data suggest that IL-6 is an important pathogenic mediator in polyarticular and pauciarticular JCA.
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M3 - Article
VL - 10
SP - 493
EP - 498
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - 5
ER -