Serum ion levels after ceramic-on-ceramic and metal-on-metal total hip arthroplasty: 8-Year minimum follow-up

Lucia Savarino, Giovanni Padovani, Massimo Ferretti, Michelina Greco, Elisabetta Cenni, Giorgio Perrone, Francesco Greco, Nicola Baldini, Armando Giunti

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Alternative bearing surfaces for total hip arthroplasty, such as metal-on-metal and ceramic-on-ceramic, offer the potential to reduce mechanical wear and osteolysis. In the short and medium term, the second generation of metal-on-metal bearings demonstrated high systemic metal ion levels, whereas ceramic-on-ceramic bearings showed the lowest ones. We aimed to verify whether the long-term ion release in metal-on-metal subjects was still relevant at a median 10-year follow-up, and whether a fretting process at the modular junctions occurred in ceramic-on-ceramic patients and induced an ion dissemination. Serum levels were measured in 32 patients with alumina-onalumina implants (group A), in 16 subjects with metal-on-metal implants (group B), and in 47 healthy subjects (group C). Group B results were compared with medium-term findings. Cobalt and chromium levels were significantly higher in metal-on-metal implants than in ceramic-on-ceramic ones and controls. Nevertheless, ion levels showed a tendency to decrease in comparison with medium-term content. In ceramic-on-ceramic implants, ion values were not significantly different from controls. Both in groups A and B, aluminum and titanium release were not significantly different from controls. In conclusion, negligible serum metal ion content was revealed in ceramic-on-ceramic patients. On the contrary, due to the higher ion release, metal-on-metal coupling must be prudently considered, especially in young patients, in order to obtain definitive conclusions.

Original languageEnglish
Pages (from-to)1569-1576
Number of pages8
JournalJournal of Orthopaedic Research
Volume26
Issue number12
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Ceramics
Arthroplasty
Hip
Metals
Ions
Serum
Osteolysis
Aluminum Oxide
Chromium
Cobalt
Titanium
Aluminum
Healthy Volunteers

Keywords

  • Alternative bearing
  • Arthroplasty
  • Ceramic-on-ceramic
  • Metal ions
  • Metal-on metal

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Savarino, L., Padovani, G., Ferretti, M., Greco, M., Cenni, E., Perrone, G., ... Giunti, A. (2008). Serum ion levels after ceramic-on-ceramic and metal-on-metal total hip arthroplasty: 8-Year minimum follow-up. Journal of Orthopaedic Research, 26(12), 1569-1576. https://doi.org/10.1002/jor.20701

Serum ion levels after ceramic-on-ceramic and metal-on-metal total hip arthroplasty : 8-Year minimum follow-up. / Savarino, Lucia; Padovani, Giovanni; Ferretti, Massimo; Greco, Michelina; Cenni, Elisabetta; Perrone, Giorgio; Greco, Francesco; Baldini, Nicola; Giunti, Armando.

In: Journal of Orthopaedic Research, Vol. 26, No. 12, 12.2008, p. 1569-1576.

Research output: Contribution to journalArticle

Savarino, L, Padovani, G, Ferretti, M, Greco, M, Cenni, E, Perrone, G, Greco, F, Baldini, N & Giunti, A 2008, 'Serum ion levels after ceramic-on-ceramic and metal-on-metal total hip arthroplasty: 8-Year minimum follow-up', Journal of Orthopaedic Research, vol. 26, no. 12, pp. 1569-1576. https://doi.org/10.1002/jor.20701
Savarino, Lucia ; Padovani, Giovanni ; Ferretti, Massimo ; Greco, Michelina ; Cenni, Elisabetta ; Perrone, Giorgio ; Greco, Francesco ; Baldini, Nicola ; Giunti, Armando. / Serum ion levels after ceramic-on-ceramic and metal-on-metal total hip arthroplasty : 8-Year minimum follow-up. In: Journal of Orthopaedic Research. 2008 ; Vol. 26, No. 12. pp. 1569-1576.
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