Serum lactate in liver resection with intermittent Pringle maneuver: the “square-root- shape

Enrico Giustiniano, Fabio Procopio, Guido Costa, Laura Rocchi, Nadia Ruggieri, Stefania Cantoni, Paola C. Zito, Yari Gollo, Guido Torzilli, Ferdinando Raimondi

Research output: Contribution to journalArticle

Abstract

Background: Serum lactate (sLac) concentration during liver resection with intermittent hepatic hilum clamping (i.e. Pringle maneuver, PM) was retrospectively investigated. Methods: A total of 133 patients who underwent liver resection were enrolled. We analyzed the sLac peri-operatively. Correlations were searched between the PM and lactatemia and its variations (i.e. lactate clearance, cLac) and other factors which it might be related to. Lactatemia in triplicate intraoperatively was recorded, just after the awakening, and 1 and 2 h later. The cLac between two consecutive measurements [(sLac1 − sLac2)/sLac1] was computed. Results: A reliable dependence of sLac was found from the cumulative PM. More than 76 min of cumulative Pringle Time (cPT) exposed patients to a worse cLac at the end of the resection phase (P < 0.0001). We found cPT >76 min, global operation time >365 min and bleeding >225 ml to be predictors of hyperlactatemia (sLac >4 mmol/L). Normal liver resulted as a risk factor for hyperlactatemia and steatosis was not (P = 0.030 vs. P = 0.325). Finally, cLac showed a “square-root- shape, just like the mathematical operation sign. Conclusions: Lactatemia during liver resection depends on the duration of PM, bleeding and the duration of the operation. Normal liver may expose the patient to the risk of hyperlactatemia.

Original languageEnglish
Pages (from-to)627-636
Number of pages10
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume24
Issue number11
DOIs
Publication statusPublished - Nov 1 2017

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Lactic Acid
Liver
Serum
Hemorrhage
Constriction
Hyperlactatemia

Keywords

  • Hepatic resection
  • Lactate clearance
  • Pringle maneuver

ASJC Scopus subject areas

  • Surgery
  • Hepatology

Cite this

Serum lactate in liver resection with intermittent Pringle maneuver : the “square-root- shape. / Giustiniano, Enrico; Procopio, Fabio; Costa, Guido; Rocchi, Laura; Ruggieri, Nadia; Cantoni, Stefania; Zito, Paola C.; Gollo, Yari; Torzilli, Guido; Raimondi, Ferdinando.

In: Journal of Hepato-Biliary-Pancreatic Sciences, Vol. 24, No. 11, 01.11.2017, p. 627-636.

Research output: Contribution to journalArticle

Giustiniano, E, Procopio, F, Costa, G, Rocchi, L, Ruggieri, N, Cantoni, S, Zito, PC, Gollo, Y, Torzilli, G & Raimondi, F 2017, 'Serum lactate in liver resection with intermittent Pringle maneuver: the “square-root- shape', Journal of Hepato-Biliary-Pancreatic Sciences, vol. 24, no. 11, pp. 627-636. https://doi.org/10.1002/jhbp.501
Giustiniano, Enrico ; Procopio, Fabio ; Costa, Guido ; Rocchi, Laura ; Ruggieri, Nadia ; Cantoni, Stefania ; Zito, Paola C. ; Gollo, Yari ; Torzilli, Guido ; Raimondi, Ferdinando. / Serum lactate in liver resection with intermittent Pringle maneuver : the “square-root- shape. In: Journal of Hepato-Biliary-Pancreatic Sciences. 2017 ; Vol. 24, No. 11. pp. 627-636.
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T2 - the “square-root- shape

AU - Giustiniano, Enrico

AU - Procopio, Fabio

AU - Costa, Guido

AU - Rocchi, Laura

AU - Ruggieri, Nadia

AU - Cantoni, Stefania

AU - Zito, Paola C.

AU - Gollo, Yari

AU - Torzilli, Guido

AU - Raimondi, Ferdinando

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Background: Serum lactate (sLac) concentration during liver resection with intermittent hepatic hilum clamping (i.e. Pringle maneuver, PM) was retrospectively investigated. Methods: A total of 133 patients who underwent liver resection were enrolled. We analyzed the sLac peri-operatively. Correlations were searched between the PM and lactatemia and its variations (i.e. lactate clearance, cLac) and other factors which it might be related to. Lactatemia in triplicate intraoperatively was recorded, just after the awakening, and 1 and 2 h later. The cLac between two consecutive measurements [(sLac1 − sLac2)/sLac1] was computed. Results: A reliable dependence of sLac was found from the cumulative PM. More than 76 min of cumulative Pringle Time (cPT) exposed patients to a worse cLac at the end of the resection phase (P < 0.0001). We found cPT >76 min, global operation time >365 min and bleeding >225 ml to be predictors of hyperlactatemia (sLac >4 mmol/L). Normal liver resulted as a risk factor for hyperlactatemia and steatosis was not (P = 0.030 vs. P = 0.325). Finally, cLac showed a “square-root- shape, just like the mathematical operation sign. Conclusions: Lactatemia during liver resection depends on the duration of PM, bleeding and the duration of the operation. Normal liver may expose the patient to the risk of hyperlactatemia.

AB - Background: Serum lactate (sLac) concentration during liver resection with intermittent hepatic hilum clamping (i.e. Pringle maneuver, PM) was retrospectively investigated. Methods: A total of 133 patients who underwent liver resection were enrolled. We analyzed the sLac peri-operatively. Correlations were searched between the PM and lactatemia and its variations (i.e. lactate clearance, cLac) and other factors which it might be related to. Lactatemia in triplicate intraoperatively was recorded, just after the awakening, and 1 and 2 h later. The cLac between two consecutive measurements [(sLac1 − sLac2)/sLac1] was computed. Results: A reliable dependence of sLac was found from the cumulative PM. More than 76 min of cumulative Pringle Time (cPT) exposed patients to a worse cLac at the end of the resection phase (P < 0.0001). We found cPT >76 min, global operation time >365 min and bleeding >225 ml to be predictors of hyperlactatemia (sLac >4 mmol/L). Normal liver resulted as a risk factor for hyperlactatemia and steatosis was not (P = 0.030 vs. P = 0.325). Finally, cLac showed a “square-root- shape, just like the mathematical operation sign. Conclusions: Lactatemia during liver resection depends on the duration of PM, bleeding and the duration of the operation. Normal liver may expose the patient to the risk of hyperlactatemia.

KW - Hepatic resection

KW - Lactate clearance

KW - Pringle maneuver

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