Serum LAIR-2 Is Increased in Autoimmune Thyroid Diseases

Rita Simone, Giampaola Pesce, Princey Antola, Domenico F. Merlo, Marcello Bagnasco, Daniele Saverino

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Leukocyte-associated Ig-like receptor (LAIR) is a small family-receptor able to inhibit immune cell function via collagen binding. It exists as both membrane-bound and soluble forms. LAIR-1 functions as an inhibitory receptor on natural killer cells, T lymphocytes and monocytes. In addition to LAIR-1, the human genome encodes LAIR-2, a soluble homolog. Several studies have focused on LAIR-1, whereas few investigations concentrate on the expression and function of LAIR-2. We demonstrate the presence of high LAIR-2 levels in 74/80 sera from patients with autoimmune thyroid diseases (both Graves' disease and autoimmune thyroiditis). LAIR-2 levels seemed not to be related to specific clinical manifestations, such as thyroid functions (hypo- or hyperthyroidism), or specific clinical features (such as ophtalmopathy). In addition, serum LAIR-2 is able, in vitro, to bind its natural ligand, collagen. Since LAIR-2 has been found to have higher affinity for collagens than LAIR-1 did, we hypothesize a potential regulating capability of serum LAIR-2 in finally regulating the inhibitory capability of LAIR-1.

Original languageEnglish
Article numbere63282
JournalPLoS One
Volume8
Issue number5
DOIs
Publication statusPublished - May 14 2013

Fingerprint

thyroid diseases
Thyroid Diseases
Autoimmune Diseases
leukocytes
Leukocytes
receptors
Collagen
Serum
T-cells
Genes
collagen
Ligands
Membranes
Natural Killer Cell Receptors
Autoimmune Thyroiditis
Graves Disease
hyperthyroidism
thyroid function
Human Genome
Hyperthyroidism

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Simone, R., Pesce, G., Antola, P., Merlo, D. F., Bagnasco, M., & Saverino, D. (2013). Serum LAIR-2 Is Increased in Autoimmune Thyroid Diseases. PLoS One, 8(5), [e63282]. https://doi.org/10.1371/journal.pone.0063282

Serum LAIR-2 Is Increased in Autoimmune Thyroid Diseases. / Simone, Rita; Pesce, Giampaola; Antola, Princey; Merlo, Domenico F.; Bagnasco, Marcello; Saverino, Daniele.

In: PLoS One, Vol. 8, No. 5, e63282, 14.05.2013.

Research output: Contribution to journalArticle

Simone, R, Pesce, G, Antola, P, Merlo, DF, Bagnasco, M & Saverino, D 2013, 'Serum LAIR-2 Is Increased in Autoimmune Thyroid Diseases', PLoS One, vol. 8, no. 5, e63282. https://doi.org/10.1371/journal.pone.0063282
Simone R, Pesce G, Antola P, Merlo DF, Bagnasco M, Saverino D. Serum LAIR-2 Is Increased in Autoimmune Thyroid Diseases. PLoS One. 2013 May 14;8(5). e63282. https://doi.org/10.1371/journal.pone.0063282
Simone, Rita ; Pesce, Giampaola ; Antola, Princey ; Merlo, Domenico F. ; Bagnasco, Marcello ; Saverino, Daniele. / Serum LAIR-2 Is Increased in Autoimmune Thyroid Diseases. In: PLoS One. 2013 ; Vol. 8, No. 5.
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